K. Christman

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

This study shows that engineered vasculature enhances the function of stem cell-derived islet organoids by improving calcium influx and insulin secretion in beta-cells.

Repeated birth injuries lead to pelvic floor muscle dysfunction and impairment in regeneration

This study shows that repeated birth injuries in rats lead to long-term pelvic floor muscle dysfunction and impaired regeneration.

Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to the Heart post Myocardial Infarction

This paper develops enzyme-responsive nanoparticles that deliver an MMP inhibitor to the heart after myocardial infarction, showing targeted retention and controlled drug release.

The role of muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury

This study shows that muscle stem cells and fibro-adipogenic progenitors are essential for pelvic floor muscle recovery after birth injury, as their loss impairs regeneration in a rat model.

Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel

This paper develops a catechol-functionalized oxime hydrogel to prevent post-surgical cardiac adhesions, showing improved tissue retention and reduced adhesion severity in animal models.

Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model

This study investigates how a myocardial matrix hydrogel reduces negative left ventricular remodeling in chronic myocardial infarction by modulating immune response and gene expression.

Immunomodulatory Contribution of Mast Cells to the Regenerative Biomaterial Microenvironment

This study shows mast cells regulate immune response to regenerative biomaterials, with sex-specific effects on macrophage polarization and inflammation.

Myocardial matrix material supports a proliferative microenvironment for cardiomyocytes

This study shows that myocardial matrix hydrogel promotes cardiomyocyte proliferation by scavenging ROS and supporting cell cycle progression in vitro and in vivo.