Author

C. L. Brooks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:protein structure· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. K. Mapp· 2 shared J. M. Garlick· 2 shared A. L. Hussain· 1 shared A. L. Peiffer· 1 shared A. Peiffer· 1 shared G. Tamayo-Castillo· 1 shared I. Artsimovitch· 1 shared J. A. Yates· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

A. K. Mapp

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Guiding Discovery of Protein Sequence-Structure-Function Modeling

A. L. Hussain, C. L. Brooks

The paper develops an in silico sequence-structure-function pipeline using AlphaFold2 and FFT docking to predict protein function, validated against experimental data on fungal monooxygenases.

bioRxiv · Jul 14, 2023Biophysics

Norstictic acid is a selective allosteric transcriptional regulator

J. M. Garlick, S. M. Sturlis, P. A. Bruno, J. A. Yates, A. Peiffer, Y. Liu, L. Goo, L. Bao, S. De Salle, G. Tamayo-Castillo, C. L. Brooks, S. D. Merajver, A. K. Mapp

This study identifies norstictic acid as a selective allosteric inhibitor of Med25-mediated transcriptional interactions, showing its effect in vitro and in a breast cancer model.

bioRxiv · Mar 26, 2021Biochemistry

TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform

A. L. Peiffer, J. M. Garlick, Y. Wu, M. B. Soellner, C. L. Brooks, A. K. Mapp

The paper identifies TMPRSS2 inhibitors using a combination of virtual screening and biochemical assays, revealing both covalent and non-covalent inhibitors.

bioRxiv · Mar 22, 2021Biochemistry

Ligand Modulates Cross-Coupling between Riboswitch Folding and Transcriptional Pausing

J. R. Widom, Y. A. Nedialkov, V. Rai, R. Hayes, C. L. Brooks, I. Artsimovitch, N. G. Walter

The paper investigates how ligand binding affects the interaction between riboswitch folding and transcriptional pausing in bacterial RNA polymerase.

bioRxiv · Jun 19, 2018Biophysics