L. Goo

Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection

The paper identifies TBC1D24 and SV2B as host factors required for antibody-dependent enhancement of dengue virus infection, beyond the role of FcgR.

Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses

The paper uses single-cell transcriptomics to identify new broadly neutralizing antibodies against flaviviruses, including an IgA1 isotype with unique neutralizing properties.

The effect of single mutations in Zika virus envelope on escape from broadly neutralizing antibodies

This study identifies how single mutations in Zika virus envelope protein affect neutralization by broadly and narrowly specific antibodies, finding that broad antibodies are harder to escape.

Defining the impact of flavivirus envelope protein glycosylation on sensitivity to broadly neutralizing antibodies

This paper investigates how glycosylation of flavivirus envelope proteins affects neutralization by broadly neutralizing antibodies, finding that glycosylation modulates antibody potency in unexpected ways.

Norstictic acid is a selective allosteric transcriptional regulator

This study identifies norstictic acid as a selective allosteric inhibitor of Med25-mediated transcriptional interactions, showing its effect in vitro and in a breast cancer model.

Functional characterization and lineage analysis of broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

The paper identifies two broadly neutralizing antibodies against dengue virus through single B cell transcriptomics and characterizes their epitopes and evolutionary pathways.