Author

C. L. Lavine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:virus· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. Chen· 5 shared M. S. Seaman· 5 shared H. Peng· 4 shared J. Lu· 4 shared S. Rits-Volloch· 4 shared Y. Cai· 4 shared A. Gautam· 3 shared H. Zhu· 3 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

B. Chen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Antibody-mediated cell entry of SARS-CoV-2

M. G. Kibria, C. L. Lavine, W. Tang, S. Wang, H. Gao, W. Shi, H. Zhu, J. Voyer, S. Rits-Volloch, F. Keerti, C. Bi, H. Peng, D. Wesemann, J. Lu, H. Xie, , B. Chen

This study shows that certain monoclonal antibodies can replace ACE2 to mediate SARS-CoV-2 entry into cells, indicating that ACE2 is not essential for viral infection.

bioRxiv · Feb 20, 2023 · PreprintMicrobiology

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

J. Zhang, T. Xiao, Y. Cai, C. L. Lavine, H. Peng, H. Zhu, K. Anand, P. Tong, A. Gautam, M. L. Mayer, R. M. Walsh, S. Rits-Volloch, D. R. Wesemann, W. Yang, M. S. Seaman, , B. Chen

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

bioRxiv · Aug 17, 2021Biochemistry

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

Y. Cai, J. Zhang, T. Xiao, C. L. Lavine, S. Rawson, H. Peng, H. Zhu, K. Anand, P. Tong, A. Gautam, S. Lu, S. Sterling, R. M. Walsh, S. Rits-Volloch, J. Lu, , B. Chen

This study reports cryo-EM structures of SARS-CoV-2 variants B.1.1.7 and B.1.351, revealing mutations that enhance infectivity and immune evasion.

bioRxiv · Apr 13, 2021Biochemistry

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

P. Tong, A. Gautam, I. Windsor, M. Travers, Y. Chen, N. Garcia, N. Whiteman, L. McKay, F. J. N. Lelis, S. Habibi, Y. Cai, L. J. Rennick, W. P. Duprex, K. McCarthy, C. L. Lavine, , D. R. Wesemann

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

bioRxiv · Mar 10, 2021Immunology

A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro

T. Xiao, J. Lu, J. Zhang, R. I. Johnson, L. G. A. McKay, N. Storm, C. L. Lavine, H. Peng, Y. Cai, S. Rits-Volloch, S. Lu, B. D. Quinlan, M. Farzan, M. S. Seaman, A. Griffiths, B. Chen

This study creates a trimeric ACE2 variant with high affinity for SARS-CoV-2 spike protein and shows it inhibits viral infection in cell culture.

Nature Structural & Molecular Biology · Feb 1, 2021Peer-reviewedMicrobiology