Author
R. I. Johnson
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2020-2023 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 26 mutual co-author links5 papers
Recent·Most cited
Preclinical Efficacy of IMM-BCP-01, a Highly Active Patient-Derived Anti-SARS-CoV-2 Antibody Cocktail
P. A. Nikitin, J. M. DiMuzio, J. P. Dowling, N. B. Patel, J. L. Bingaman-Steele, C. Nicolescu, B. C. Heimbach, N. Henriquez, E. L. Sikorsky, A. Polley, R. J. Howanski, M. Nath, H. Shukla, S. M. Scheaffer, J. P. Finn, , M. K. Robinson
The paper identifies and characterizes an antibody cocktail, IMM-BCP-01, that neutralizes SARS-CoV-2 variants in vitro and inhibits infection in vivo through Spike Trimer dissociation and effector responses.
bioRxiv · Oct 18, 2021 · PreprintImmunology
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro
T. Xiao, J. Lu, J. Zhang, R. I. Johnson, L. G. A. McKay, N. Storm, C. L. Lavine, H. Peng, Y. Cai, S. Rits-Volloch, S. Lu, B. D. Quinlan, M. Farzan, M. S. Seaman, A. Griffiths, B. Chen
This study creates a trimeric ACE2 variant with high affinity for SARS-CoV-2 spike protein and shows it inhibits viral infection in cell culture.
Nature Structural & Molecular Biology · Feb 1, 2021Peer-reviewedMicrobiology
Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates
N. Zabaleta, W. Dai, U. Bhatt, J. A. Chichester, J. Sanmiguel, R. Estelien, K. T. Michalson, C. Diop, D. Maciorowski, W. Qi, E. Hudspeth, A. Cucalon, C. D. Dyer, M. B. Pampena, J. J. Knox, , L. H. Vandenberghe
This paper evaluates an AAV-based COVID-19 vaccine in mice and non-human primates, showing sustained neutralizing antibodies and memory T-cells, with room-temperature stability and scalable production.
bioRxiv · Jan 5, 2021 · PreprintImmunology
Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2
S. A. Clark, L. E. Clark, J. Pan, A. Coscia, L. G. A. McKay, S. Shankar, R. I. Johnson, A. Griffiths, J. Abraham
The paper identifies germline-biased neutralizing antibodies against SARS-CoV-2 and shows that affinity gains do not always correlate with neutralization potency.
bioRxiv · Nov 13, 2020Microbiology