Author

K. Anand

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4 Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:virus· 4 Organism:human· 3 Assay:proteomics· 3 Assay:structural biology· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

A. Gautam· 4 shared B. Chen· 4 shared H. Peng· 4 shared H. Zhu· 4 shared J. Lu· 4 shared J. Zhang· 4 shared P. Tong· 4 shared S. Rits-Volloch· 4 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

A. Gautam

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Structural basis of Cdk7 activation by dual T-loop phosphorylation

R. Duster, K. Anand, S. C. Binder, M. Schmitz, K. Gatterdam, R. P. Fisher, M. Geyer

This study reports the crystal structure of fully activated Cdk7/Cyclin H/Mat1 complex with dual T-loop phosphorylations, revealing their distinct roles in kinase activity and substrate recognition.

bioRxiv · Feb 14, 2024 · PreprintBiochemistry

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA

A. K. de Regt, K. Anand, K. Ciupka, K. Gatterdam, B. Putschli, D. Fusshoeller, D. Hilbig, A. Kirchhoff, C. Hunkler, S. Wolter, A. Gruenewald, C. Schuberth-Wagner, J. Ludwig, K. Paeschke, E. Bartok, , M. Schlee

This study identifies an isoleucine residue in RIG-I that prevents recognition of 5p-RNA, thereby maintaining immune tolerance to mitochondrial RNA.

bioRxiv · Aug 2, 2022Immunology

Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike

J. Zhang, T. Weichun, H. Gao, C. Lavine, W. Shi, H. Peng, H. Zhu, K. Anand, M. Kosikova, H. J. Kwon, P. Tong, A. Gautam, S. Rits-Volloch, S. Wang, M. L. Mayer, , B. Chen

This study characterizes the structural, functional, and antigenic properties of SARS-CoV-2 Omicron BA.2 spike protein and compares its replication efficiency with previous variants.

bioRxiv · Apr 28, 2022 · PreprintMicrobiology

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

J. Zhang, Y. Cai, C. Lavine, H. Peng, H. Zhu, K. Anand, P. Tong, A. Gautam, M. Mayer, S. Rits-Volloch, S. Wang, P. Sliz, D. Wesemann, W. Yang, M. Seaman, , B. Chen

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

bioRxiv · Jan 11, 2022Biochemistry

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

J. Zhang, T. Xiao, Y. Cai, C. L. Lavine, H. Peng, H. Zhu, K. Anand, P. Tong, A. Gautam, M. L. Mayer, R. M. Walsh, S. Rits-Volloch, D. R. Wesemann, W. Yang, M. S. Seaman, , B. Chen

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

bioRxiv · Aug 17, 2021Biochemistry

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

Y. Cai, J. Zhang, T. Xiao, C. L. Lavine, S. Rawson, H. Peng, H. Zhu, K. Anand, P. Tong, A. Gautam, S. Lu, S. Sterling, R. M. Walsh, S. Rits-Volloch, J. Lu, , B. Chen

This study reports cryo-EM structures of SARS-CoV-2 variants B.1.1.7 and B.1.351, revealing mutations that enhance infectivity and immune evasion.

bioRxiv · Apr 13, 2021Biochemistry

Mycobacterium tuberculosis SufR Responds to Nitric oxide via its 4Fe-4S cluster and Regulates Fe-S cluster Biogenesis for Persistence in Mice

K. Anand, A. Tripathi, K. Shukla, N. Malhotra, A. Jamithireddy, R. K. Jha, S. N. Chaudhury, R. S. Rajmani, A. Ramesh, V. Nagaraja, B. Gopal, G. Nagaraju, A. S. N. Seshasayee, A. Singh

This paper shows that Mtb's SufR senses NO via its 4Fe-4S cluster, regulates Fe-S cluster biogenesis, and supports persistence in mice.

bioRxiv · Aug 10, 2020 · PreprintMicrobiology

Efficacy of the β-lactam\β-lactamase inhibitor combination is linked to WhiB4 mediated changes in redox physiology of Mycobacterium tuberculosis

S. Mishra, P. Shukla, A. Bhaskar, K. Anand, P. Baloni, R. K. Jha, A. K. Mohan, R. S. Rajmani, V. Nagaraja, N. Chandra, A. Singh

This paper shows that the effectiveness of the β-lactam/β-lactamase inhibitor combination against Mtb depends on WhiB4-regulated redox changes, with higher mycothiol redox potential enhancing drug efficacy.

bioRxiv · Jan 30, 2017Microbiology