P. Kogner

METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma

This study shows METTL3 modifies TERRA lncRNA with m6A, promoting R-loop formation that targets TERRA to telomeres, and inhibiting METTL3 disrupts this process in ALT+ neuroblastoma cells.

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

This study identifies DHODH as a prognostic marker and therapeutic target in neuroblastoma, showing its inhibition improves survival in preclinical models and suggests combination therapy with temozolomide.

Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumors.

The paper identifies distinct cellular identities in low and high-risk neuroblastoma tumors using single-nuclei transcriptomes, linking them to clinical outcomes and age at diagnosis.

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors.

This study identifies PPM1D as an oncogene and therapeutic target in neuroblastoma by showing its role in p53 inactivation and tumor growth.

Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma

The paper identifies a subpopulation of malignant Schwann cell precursor-like cells in neuroblastoma that connects adrenergic and mesenchymal tumor cells, suggesting intratumoral plasticity mechanisms.

Alternative splicing in neuroblastoma generates RNA-fusion transcripts and is associated with vulnerability to spliceosome inhibitors

This study identifies splicing-dependent RNA-fusions in neuroblastoma and shows spliceosome inhibition reduces tumor growth.