C. M. R. Blackburn

This study shows lipin-1 regulates lipid catabolism in pro-resolving macrophages by promoting fatty acid oxidation and TCA cycle function during IL-4 responses.

This study shows that lipin-1's transcriptional co-regulatory activity protects against atherosclerosis, while its enzymatic activity promotes it, using a mouse model with myeloid cell-specific lipin-1 deletion.

This study shows that lipin-1's transcriptional co-regulator activity is necessary for macrophage polarization and wound healing, as its absence impairs IL-4 mediated gene expression and tissue repair.