Author

R. M. Schilke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. D. Woolard· 4 shared B. N. Finck· 3 shared C. M. R. Blackburn· 3 shared R. S. Scott· 2 shared A. E. Vozenilek· 1 shared A. Gowlikar· 1 shared A. Yurdagul· 1 shared A. Yurochko· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersImmunology

M. D. Woolard

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Lipin-1 restrains macrophage lipid synthesis to promote inflammation resolution.

T. T. Bamgbose, R. M. Schilke, O. O. Igiehon, E. H. Nkadi, D. Custis, S. Bharrhan, B. Schwarz, E. Bohrnsen, C. Bosio, R. S. Scott, A. Yurdagul, B. Finck, M. Woolard

This study shows that lipin-1 limits macrophage lipid synthesis, which supports inflammation resolution by enhancing efferocytosis.

bioRxiv · Oct 23, 2023Immunology

Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis

C. S. Stevens, K. Y. Oguntuyo, S. Kowdle, A. Gowlikar, M. N. Siddiquey, J. A. Acklin, G. Haas, R. M. Schilke, M. D. Woolard, H. Zhang, L. Brambilla, S. Ikegame, C.-t. Hung, J. K. Lim, R. W. Cross, , B. Lee

This study investigates the role of alpha-1-antitrypsin in inhibiting SARS-CoV-2 entry and shows variant-dependent effects on its ability to block different viral strains.

bioRxiv · Aug 14, 2020 · PreprintMicrobiology

Lipin-1 regulates lipid catabolism in pro-resolving macrophages.

R. M. Schilke, C. M. R. Blackburn, S. Rao, D. M. Krzywanski, B. N. Finck, M. D. Woolard

This study shows lipin-1 regulates lipid catabolism in pro-resolving macrophages by promoting fatty acid oxidation and TCA cycle function during IL-4 responses.

bioRxiv · Jun 3, 2020 · PreprintImmunology

Macrophage-associated lipin-1 transcriptional co-regulatory activity is involved in atherosclerosis

C. M. R. Blackburn, R. M. Schilke, A. E. Vozenilek, B. N. Finck, M. D. Woolard

This study shows that lipin-1's transcriptional co-regulatory activity protects against atherosclerosis, while its enzymatic activity promotes it, using a mouse model with myeloid cell-specific lipin-1 deletion.

bioRxiv · Jun 2, 2020 · PreprintImmunology

Lipin-1 contributes to IL-4 mediated macrophage polarization

S. Chandra, R. M. Schilke, C. M. R. Blackburn, A. Yurochko, R. Mirza, R. S. Scott, B. N. Finck, M. D. Woolard

This study shows that lipin-1's transcriptional co-regulator activity is necessary for macrophage polarization and wound healing, as its absence impairs IL-4 mediated gene expression and tissue repair.

bioRxiv · Dec 23, 2019Immunology