Author

C. M. Weight

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. S. Heyderman· 3 shared E. Ramos-Sevillano· 2 shared J. Reine· 2 shared J. S. Brown· 2 shared M. Betts· 2 shared M. Noursadeghi· 2 shared A. Houhou-Ousalah· 1 shared C. Jolly· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

R. S. Heyderman

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Author profile →

3 papers

Recent·Most cited

Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae

J. M. Chan, E. Ramos-Sevillano, M. Betts, H. U. Wilson, C. M. Weight, A. Houhou-Ousalah, G. Pollara, J. S. Brown, R. S. Heyderman

This study investigates how pneumococcal lipoproteins mediate epithelial microinvasion and finds that differential lipoprotein repertoires do not significantly impact microinvasion, suggesting post-translational modifications may be responsible.

bioRxiv · Oct 18, 2023 · PreprintMicrobiology

Disease-attenuated pneumococcal biosynthesis gene mutants invade the mucosal epithelium and induce innate immunity

C. M. Weight, G. M. Pollara, M. Betts, R. Ragazzini, M. Connor, E. Ramos-Sevillano, J. Reine, M. Whelan, J. A. Guerra-Assuncao, P. Bonfanti, C. Jolly, M. Noursadeghi, D. Ferreira, J. Brown, R. S. Heyderman

This paper shows that disease-attenuated pneumococcal mutants retain epithelial microinvasion but show reduced transmigration and altered inflammatory responses.

bioRxiv · Jun 15, 2023Microbiology

Epithelial micro-invasion by Streptococcus pneumoniae induces epithelial-derived innate immunity during colonisation at the human mucosal surface

C. M. Weight, C. Venturini, S. Pojar, S. Jochems, J. Reine, E. Nikolaou, C. Solorzano, M. Noursadeghi, J. S. Brown, D. M. Ferreira, R. S. Heyderman

This study shows that Streptococcus pneumoniae colonizes human mucosa via microinvasion, triggering epithelial innate immunity and influencing bacterial clearance.

bioRxiv · Mar 30, 2019Immunology