Author

E. Nikolaou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:DNA methylation· 1 Assay:flow cytometry· 1 Assay:metagenomics· 1

Frequent Co-Authors

E. Mitsi· 6 shared J. Reine· 6 shared S. Pojar· 6 shared C. Solorzano· 5 shared D. M. Ferreira· 5 shared H. Hill· 5 shared J. Rylance· 4 shared S. B. Gordon· 4 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

E. Mitsi

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Streptococcus pneumoniae serotype 33G: genetic, serological, and structural analysis of a new capsule type

S. Manna, J. P. Werren, B. D. Ortika, B. Bellich, C. L. Pell, E. Nikolaou, I. Gjuroski, S. W. Lo, J. Hinds, O. Tundev, E. M. Dunne, B. D. Gessner, S. D. Bentley, F. Russell, E. K. Mulholland, , C. Satzke

This study identifies and characterizes a new Streptococcus pneumoniae serotype, 33G, through genetic, serological, and structural analysis of isolates from Mongolia.

bioRxiv · Sep 11, 2023 · PreprintMicrobiology

Epithelial micro-invasion by Streptococcus pneumoniae induces epithelial-derived innate immunity during colonisation at the human mucosal surface

C. M. Weight, C. Venturini, S. Pojar, S. Jochems, J. Reine, E. Nikolaou, C. Solorzano, M. Noursadeghi, J. S. Brown, D. M. Ferreira, R. S. Heyderman

This study shows that Streptococcus pneumoniae colonizes human mucosa via microinvasion, triggering epithelial innate immunity and influencing bacterial clearance.

bioRxiv · Mar 30, 2019Immunology

Minimally-invasive nasal sampling in children offers accurate pneumococcal colonization detection

E. Nikolaou, A. Blizard, S. Pojar, E. Mitsi, E. L. German, J. Reine, H. Hill, P. S. McNamara, A. M. Collins, D. M. Ferreira, S. P. Jochems

This study shows that nasal lining fluid filter strips provide equal pneumococcal detection sensitivity to deep nasopharyngeal swabs in children, offering a less unpleasant alternative.

bioRxiv · Mar 13, 2019Microbiology

Efficacy of PCV vaccine is primarily mediated by controlling pneumococcal colonisation density

E. L. German, C. Solorzano, S. Sunny, F. Dunne, J. F. Gritzfeld, E. Mitsi, E. Nikolaou, A. D. Hyder-Wright, A. M. Collins, S. B. Gordon, D. Ferreira

This study re-evaluates PCV-13 efficacy using molecular methods, finding reduced colonisation acquisition and density, suggesting vaccine impact is primarily through controlling colonisation density.

bioRxiv · Feb 14, 2019 · PreprintMicrobiology

Defining mucosal immunity using mass cytometry following experimental human pneumococcal challenge

S. P. Jochems, K. de Ruiter, C. Solorzano, A. Voskamp, E. Mitsi, E. Nikolaou, B. F. Carniel, S. Pojar, E. German, J. Reine, A. Soares-Schanoski, H. Hill, R. Robinson, A. D. Hyder-Wright, C. Weight, , D. M. Ferreira

The paper uses mass cytometry to analyze nasal immune cells after pneumococcal challenge, identifying immune changes linked to colonization and host-pathogen interactions.

bioRxiv · Feb 11, 2019Immunology

Experimental Human Challenge Reveals Distinct Mechanisms of Acquisition or Protection Against Pneumococcal Colonization

E. Nikolaou, S. P. Jochems, E. Mitsi, S. Pojar, E. Negera, J. Reine, B. Carniel, A. Soares-Schanoski, V. Connor, H. Adler, S. R. Zaidi, C. Hales, H. Hill, A. Hyder-Wright, S. B. Gordon, , D. Ferreira

This study uses a human challenge model to show that nasal colonization by Streptococcus pneumoniae can take up to 24 hours and identifies two distinct clearance mechanisms involving neutrophils.

bioRxiv · Nov 5, 2018 · PreprintImmunology

Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage

S. P. Jochems, F. Marcon, B. F. Carniel, M. Holloway, E. Mitsi, E. Smith, J. F. Gritzfeld, C. Solorzano, J. Reine, S. Pojar, E. Nikolaou, E. L. German, A. Hyder-Wright, H. Hill, C. Hales, , D. M. Ferreira

This study shows that influenza virus infection impairs innate immune responses to pneumococcal carriage in the nose, increasing bacterial density through cytokine-driven mechanisms.

bioRxiv · Jun 20, 2018Immunology

Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage

J. Rylance, W. A. de Steenhuijsen Piters, S. Pojar, E. Nikolaou, E. German, E. Mitsi, S. Jochems, B. Carniel, C. Solorzano, J. Reine, J. Gritzfeld, M. L. J. Chu, K. Arp, A. D. Hyder-Wright, H. Hill, , D. M. Ferreira

This study tests if LAIV affects pneumococcal carriage in humans, finding transient increases in bacterial density but no overall change in acquisition rates.

bioRxiv · Jun 14, 2018Immunology