J. Reine

Disease-attenuated pneumococcal biosynthesis gene mutants invade the mucosal epithelium and induce innate immunity

This paper shows that disease-attenuated pneumococcal mutants retain epithelial microinvasion but show reduced transmigration and altered inflammatory responses.

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

This study shows that hybrid immunity from infection plus vaccination generates durable lung mucosal immunity, while peripheral vaccination alone does not.

Isolation of an antimicrobial resistant, biofilm forming, Klebsiella grimontii isolate from a re-usable water bottle.

The paper isolates a Klebsiella grimontii strain from a re-usable water bottle, identifies its antimicrobial resistance and biofilm-forming capabilities, and highlights hygiene concerns for reusable bottles.

Epithelial micro-invasion by Streptococcus pneumoniae induces epithelial-derived innate immunity during colonisation at the human mucosal surface

This study shows that Streptococcus pneumoniae colonizes human mucosa via microinvasion, triggering epithelial innate immunity and influencing bacterial clearance.

Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan

This study examines age-related changes in nasal mucosal immune composition and function, finding reduced granulocytes and T cells in young children and older adults, and links pneumococcal colonization to inflammation.

Minimally-invasive nasal sampling in children offers accurate pneumococcal colonization detection

This study shows that nasal lining fluid filter strips provide equal pneumococcal detection sensitivity to deep nasopharyngeal swabs in children, offering a less unpleasant alternative.

Defining mucosal immunity using mass cytometry following experimental human pneumococcal challenge

The paper uses mass cytometry to analyze nasal immune cells after pneumococcal challenge, identifying immune changes linked to colonization and host-pathogen interactions.

Experimental Human Challenge Reveals Distinct Mechanisms of Acquisition or Protection Against Pneumococcal Colonization

This study uses a human challenge model to show that nasal colonization by Streptococcus pneumoniae can take up to 24 hours and identifies two distinct clearance mechanisms involving neutrophils.

Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage

This study shows that influenza virus infection impairs innate immune responses to pneumococcal carriage in the nose, increasing bacterial density through cytokine-driven mechanisms.

Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage

This study tests if LAIV affects pneumococcal carriage in humans, finding transient increases in bacterial density but no overall change in acquisition rates.