Author

C. Marques-da-Silva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

S. P. Kurup· 3 shared D. E. Kyle· 2 shared K. Peissig· 2 shared R. P. Baptista· 2 shared B. Poudel· 1 shared J. C. Shiau· 1 shared J. Shiau· 1 shared J. T. Harty· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

S. P. Kurup

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3 papers

Recent·Most cited

Inherently reduced expression of ASC restricts caspase-1 processing in hepatocytes and promotes Plasmodium infection

C. Marques-da-Silva, R. P. Baptista, S. P. Kurup

The paper shows that reduced ASC expression in hepatocytes limits caspase-1 processing, impairing Plasmodium control but improving vaccination outcomes when ASC is increased.

bioRxiv · Jul 10, 2023 · PreprintImmunology

Direct type I Interferon signaling in hepatocytes control malaria

C. Marques-da-Silva, K. Peissig, M. P. Walker, J. Shiau, D. E. Kyle, R. Vijay, S. E. Lindner, S. P. Kurup

This study shows that direct type I interferon signaling in infected hepatocytes is necessary and sufficient to control malaria, revealing cell-autonomous immune responses.

bioRxiv · Jan 26, 2022Immunology

Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver

C. Marques-da-Silva, B. Poudel, R. P. Baptista, K. Peissig, L. S. Hancox, J. C. Shiau, L. Pewe, M. J. Shears, T.-D. Kanneganti, P. Sinnis, D. E. Kyle, P. Gurung, J. T. Harty, S. P. Kurup

This study shows that limited Caspase-1 cleavage in hepatocytes reduces pyroptosis and cytokine maturation, impairing malaria control, and that enhancing ASC expression improves immune response.

bioRxiv · Jan 28, 2021 · PreprintImmunology