Author

P. Gurung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Poudel· 2 shared M. S. Yorek· 2 shared T. Maretzky· 2 shared A. Teghanemt· 1 shared C. Au· 1 shared C. Marques-da-Silva· 1 shared D. E. Kyle· 1 shared D. R. Littman· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

B. Poudel

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

PfCAP-H is essential for assembly of condensin I complex and karyokinesis during asexual proliferation of Plasmodium falciparum

P. Gurung, J. P. McGee, J. D. Dvorin

This study investigates the role of PfCAP-H in condensin I complex assembly and karyokinesis during Plasmodium falciparum asexual proliferation, finding it essential for structural integrity and proper cell division.

bioRxiv · Feb 26, 2024 · PreprintCell Biology

LRRK2 G2019S promotes the development of colon cancer via modulating intestinal inflammation

Z. Kang, Y. Wang, J. Z. Gao, T. Sakaguchi, T. Maretzky, P. Gurung, S. Short, Y. Xiong

This study shows that LRRK2 G2019S promotes colon cancer by enhancing intestinal inflammation and tumor growth in mice.

bioRxiv · Jun 28, 2023Immunology

Epigenetic Programming during thymic development sets the stage for optimal function in effector T cells via DNA demethylation

A. Teghanemt, P. Pulipati, K. Day, M. S. Yorek, R. Yi, K. M. Misel, H. L. Keen, C. Au, T. Maretzky, P. Gurung, D. R. Littman, P. D. Issuree

The paper shows DNA demethylation during thymic development is essential for proper function of stimulus-responsive elements in effector T cells, impacting gene expression and immune response.

bioRxiv · May 3, 2021 · PreprintImmunology

Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver

C. Marques-da-Silva, B. Poudel, R. P. Baptista, K. Peissig, L. S. Hancox, J. C. Shiau, L. Pewe, M. J. Shears, T.-D. Kanneganti, P. Sinnis, D. E. Kyle, P. Gurung, J. T. Harty, S. P. Kurup

This study shows that limited Caspase-1 cleavage in hepatocytes reduces pyroptosis and cytokine maturation, impairing malaria control, and that enhancing ASC expression improves immune response.

bioRxiv · Jan 28, 2021 · PreprintImmunology

Leishmania major degrades murine CXCL1 - an immune evasion strategy

M. S. Yorek, B. Poudel, L. Mazgaeen, R. M. Pope, M. E. Wilson, P. Gurung

This study identifies that Leishmania major degrades murine CXCL1 via metalloproteases, impairing neutrophil recruitment and highlighting a potential therapeutic target for immune evasion.

bioRxiv · Mar 11, 2019Microbiology