Author

M. J. Shears

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 1

Frequent Co-Authors

P. Sinnis· 4 shared K. E. Swearingen· 2 shared R. L. Moritz· 2 shared A. M. Minns· 1 shared A. P. Khandhar· 1 shared A. Pandey· 1 shared A. Simpson· 1 shared A. Tripathi· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersMicrobiology

P. Sinnis

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Author profile →

7 papers

Recent·Most cited

Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine

Z. MacMillen, K. Hatzakis, A. Simpson, M. J. Shears, F. Watson, J. Erasmus, A. P. Khandhar, B. K. Wilder, S. C. Murphy, S. G. Reed, J. W. Davie, M. Avril

This paper develops an accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine that provides sterile protection with a single day regimen.

bioRxiv · May 23, 2023Immunology

Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver

C. Marques-da-Silva, B. Poudel, R. P. Baptista, K. Peissig, L. S. Hancox, J. C. Shiau, L. Pewe, M. J. Shears, T.-D. Kanneganti, P. Sinnis, D. E. Kyle, P. Gurung, J. T. Harty, S. P. Kurup

This study shows that limited Caspase-1 cleavage in hepatocytes reduces pyroptosis and cytokine maturation, impairing malaria control, and that enhancing ASC expression improves immune response.

bioRxiv · Jan 28, 2021 · PreprintImmunology

Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites

S. E. Lindner, K. E. Swearingen, M. J. Shears, M. P. Walker, E. N. Vrana, K. J. Hart, A. M. Minns, P. Sinnis, R. L. Moritz, S. H. Kappe

This study identifies two waves of translational repression in malaria sporozoite maturation using transcriptomic and proteomic data from Plasmodium species.

bioRxiv · May 20, 2019 · PreprintMicrobiology

Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodelling

N. J. Katris, S. Amiar, L. Berry, S. Dass, M. J. Shears, C. Brunet, B. Touquet, M.-A. Hakimi, G. I. McFadden, Y. Yamaryo-Botte, C. Y. Botte

This study shows that apicomplexan parasites adapt to host nutritional changes by shifting lipid acquisition between de novo synthesis and host scavenging, involving apicoplast lipid metabolism and host organelle remodeling.

bioRxiv · Mar 22, 2019Microbiology

Proteomic Analysis of Plasmodium Merosomes: The Link Between Liver and Blood Stages in Malaria

M. J. Shears, R. Sekhar Nirujogi, K. E. Swearingen, S. Renuse, S. Mishra, P. Jaipal Reddy, R. L. Moritz, A. Pandey, P. Sinnis

This paper presents the first proteomic analysis of merosomes in Plasmodium berghei, identifying 1879 proteins and highlighting shared and unique features with blood stage proteomes.

bioRxiv · Mar 16, 2019Microbiology

Generation of Transgenic Human Malaria Parasites With Strong Fluorescence in the Transmission Stages

K. J. McLean, J. Straimer, C. S. Hopp, J. Vega-Rodriguez, A. Tripathi, G. Mlambo, P. C. Doumolin, C. T. Harris, X. Tong, M. J. Shears, J. Ankarklev, B. Kafsack, D. A. Fidock, P. Sinnis

The paper generates transgenic Plasmodium falciparum parasites with fluorescent transmission stages for improved study and screening.

bioRxiv · Dec 18, 2018 · PreprintMicrobiology

O-fucosylation of thrombospondin-like repeats is required for processing of MIC2 and for efficient host cell invasion by Toxoplasma gondii tachyzoites

G. Bandini, D. R. Leon, C. M. Hoppe, Y. Zhang, C. Agop-Nersesian, M. J. Shears, L. K. Mahal, F. H. Routier, C. E. Costello, J. Samuelson

bioRxiv · Aug 2, 2018Microbiology