Author

P. Sinnis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:human· 8 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

M. J. Shears· 4 shared S. kanatani· 3 shared A. K. Tripathi· 2 shared A. Tripathi· 2 shared C. S. Hopp· 2 shared G. Mlambo· 2 shared G. Nasir· 2 shared K. E. Swearingen· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersMicrobiology

M. J. Shears

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

C. Andolina, W. Graumans, M. Guelbeogo, G.-J. v. Gemert, J. Ramjith, S. Harouna, Z. Soumanaba, R. Stoter, M. van de Vegte-Bolmer, M. Pangos, P. Sinnis, K. Collins, S. Staedke, A. Tiono, C. Drakeley, , T. Bousema

The paper quantifies sporozoite expulsion from Anopheles mosquitoes infected with P. falciparum gametocytes, finding that infection burden correlates with sporozoite expulsion.

bioRxiv · Aug 3, 2023 · PreprintMicrobiology

Transmissibility of clinically relevant atovaquone-resistant Plasmodium falciparum by anopheline mosquitoes

V. A. Balta, D. Stiffler, A. Sayeed, A. K. Tripathi, R. Elahi, G. Mlambo, R. P. Bakshi, A. G. Dziedzic, A. E. Jedlicka, E. Nenortas, K. Romero-Rodriguez, M. A. Canonizado, A. Mann, A. Owen, D. J. Sullivan, , T. A. Shapiro

This study shows that atovaquone-resistant Plasmodium falciparum mutants have severe fitness costs in mosquitoes and fail to transmit to mice, reducing the risk of drug resistance spread.

bioRxiv · Feb 7, 2023Microbiology

Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite.

G. Batugedara, X. M. Lu, S. Abel, Z. Chahine, B. Hristov, D. Williams, T. Hollin, T. Wang, A. Cort, T. Lenz, T. Thompson, J. Prudhomme, A. K. Tripathi, G. Xu, J. Cudini, , K. G. Le Roch

This study identifies and characterizes long non-coding RNAs (lncRNAs) in Plasmodium falciparum, revealing their role in gene regulation, pathogenicity, and sexual differentiation.

bioRxiv · Oct 12, 2022 · PreprintMicrobiology

Transport of Antibody into the Skin is Only Partially Dependent Upon the Neonatal Fc-Receptor

G. Nasir, P. Sinnis

This study investigates the role of FcRn in IgG transport into the skin and its impact on antibody-mediated protection against malaria.

bioRxiv · Aug 19, 2022 · PreprintImmunology

Screening the Pathogen Box Compounds for Activity Against Plasmodium falciparum Sporozoite Motility

S. kanatani, R. Elahi, S. Kanchanabhogin, N. Vartek, A. Tripathi, S. Prigge, P. Sinnis

This study screens 400 drug-like compounds from the Pathogen Box for activity against Plasmodium falciparum sporozoite motility and identifies five compounds with significant inhibitory effects.

bioRxiv · Mar 30, 2022Microbiology

The repeat region of the circumsporozoite protein is an elastic linear spring with a functional role in Plasmodium sporozoite motility

A. Balaban, S. Kanatani, J. Mitra, J. Gregory, N. Vartak, A. Sinnis-Bourozikas, F. Frischknecht, T. Ha, P. Sinnis

The study identifies the CSP repeat region as a linear spring critical for sporozoite motility and adhesion site formation in malaria parasites.

bioRxiv · May 12, 2021 · PreprintMicrobiology

Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver

C. Marques-da-Silva, B. Poudel, R. P. Baptista, K. Peissig, L. S. Hancox, J. C. Shiau, L. Pewe, M. J. Shears, T.-D. Kanneganti, P. Sinnis, D. E. Kyle, P. Gurung, J. T. Harty, S. P. Kurup

This study shows that limited Caspase-1 cleavage in hepatocytes reduces pyroptosis and cytokine maturation, impairing malaria control, and that enhancing ASC expression improves immune response.

bioRxiv · Jan 28, 2021 · PreprintImmunology

Experimental Determination of the Force of Malaria Infection Reveals a Non-Linear Relationship to Mosquito Sporozoite Loads

M. Aleshnick, V. Ganusov, G. Nasir, G. Yenokyan, P. Sinnis

The paper determines the probability of malaria infection after mosquito bites in a rodent model and finds a non-linear relationship between sporozoite load and infection likelihood.

PLOS Pathogens · May 26, 2020Peer-reviewedMicrobiology

Quantitative intravital imaging of Plasmodium falciparum sporozoites: A novel platform to test malaria intervention strategies

C. S. Hopp, S. Kanatani, N. K. Archer, R. J. Miller, H. Liu, K. Chiou, L. S. Miller, P. Sinnis

This paper develops an intravital imaging platform to study P. falciparum sporozoite motility in human skin xenografts and tests interventions against malaria sporozoites.

bioRxiv · Jul 30, 2019 · PreprintMicrobiology

Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites

S. E. Lindner, K. E. Swearingen, M. J. Shears, M. P. Walker, E. N. Vrana, K. J. Hart, A. M. Minns, P. Sinnis, R. L. Moritz, S. H. Kappe

This study identifies two waves of translational repression in malaria sporozoite maturation using transcriptomic and proteomic data from Plasmodium species.

bioRxiv · May 20, 2019 · PreprintMicrobiology

Proteomic Analysis of Plasmodium Merosomes: The Link Between Liver and Blood Stages in Malaria

M. J. Shears, R. Sekhar Nirujogi, K. E. Swearingen, S. Renuse, S. Mishra, P. Jaipal Reddy, R. L. Moritz, A. Pandey, P. Sinnis

This paper presents the first proteomic analysis of merosomes in Plasmodium berghei, identifying 1879 proteins and highlighting shared and unique features with blood stage proteomes.

bioRxiv · Mar 16, 2019Microbiology

Generation of Transgenic Human Malaria Parasites With Strong Fluorescence in the Transmission Stages

K. J. McLean, J. Straimer, C. S. Hopp, J. Vega-Rodriguez, A. Tripathi, G. Mlambo, P. C. Doumolin, C. T. Harris, X. Tong, M. J. Shears, J. Ankarklev, B. Kafsack, D. A. Fidock, P. Sinnis

The paper generates transgenic Plasmodium falciparum parasites with fluorescent transmission stages for improved study and screening.

bioRxiv · Dec 18, 2018 · PreprintMicrobiology