Author

R. P. Baptista

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

C. Marques-da-Silva· 2 shared S. P. Kurup· 2 shared A. Florentin· 1 shared B. Poudel· 1 shared C. F. Brooks· 1 shared D. E. Kyle· 1 shared D. Peng· 1 shared D. R. Stephens· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

C. Marques-da-Silva

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Inherently reduced expression of ASC restricts caspase-1 processing in hepatocytes and promotes Plasmodium infection

C. Marques-da-Silva, R. P. Baptista, S. P. Kurup

The paper shows that reduced ASC expression in hepatocytes limits caspase-1 processing, impairing Plasmodium control but improving vaccination outcomes when ASC is increased.

bioRxiv · Jul 10, 2023 · PreprintImmunology

Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver

C. Marques-da-Silva, B. Poudel, R. P. Baptista, K. Peissig, L. S. Hancox, J. C. Shiau, L. Pewe, M. J. Shears, T.-D. Kanneganti, P. Sinnis, D. E. Kyle, P. Gurung, J. T. Harty, S. P. Kurup

This study shows that limited Caspase-1 cleavage in hepatocytes reduces pyroptosis and cytokine maturation, impairing malaria control, and that enhancing ASC expression improves immune response.

bioRxiv · Jan 28, 2021 · PreprintImmunology

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease

W. Wang, D. Peng, R. P. Baptista, Y. Li, J. C. Kissinger, R. L. Tarleton

This study uses long-read sequencing and proximity ligation mapping to analyze genetic diversity in two T. cruzi strains, revealing mechanisms of gene amplification, dispersion, and recombination that contribute to immune evasion and genome evolution.

bioRxiv · Jul 15, 2020Microbiology

The Clp System in Malaria Parasites Degrades Essential Substrates to Regulate Plastid Biogenesis

A. Florentin, D. R. Stephens, C. F. Brooks, R. P. Baptista, V. Muralidharan

This study identifies the role of the Clp protease system in regulating apicoplast biogenesis in Plasmodium falciparum by demonstrating its enzymatic activity and interactions with chaperones and substrates.

bioRxiv · Nov 4, 2019Microbiology