Author

C. Mc Guinness

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. D. Griffiths· 1 shared A. M. van Oijen· 1 shared A. Pichard-Kostuch· 1 shared C. Bayly-Jones· 1 shared C. Morton· 1 shared G. H. Mansour· 1 shared H. Ghodke· 1 shared H. Yu· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

A. D. Griffiths

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2 papers

Recent·Most cited

Optimised Nanobody-based Quenchbodies for Enhanced Protein Detection

J. H. Cater, N. Elsalamouny, G. H. Mansour, S. Hutchinson, C. Mc Guinness, S. H. Mueller, R. R. Spinks, N. Shanmugam, A. Pichard-Kostuch, V. Zahoransky, H. Ghodke, M. Ribezzi-Crivellari, H. Yu, A. M. van Oijen, A. D. Griffiths, L. M. Spenkelink

This study optimizes nanobody-based quenchbodies for enhanced protein detection, achieving fluorescence increases of 1.5-2.4-fold and detecting IL-6 down to 2 nM.

bioRxiv · Mar 27, 2024Bioengineering

Single-molecule analysis of the entire perfringolysin O poreformation pathway

C. Mc Guinness, J. Walsh, C. Bayly-Jones, M. Dunstone, C. Morton, M. Christie, M. W. Parker, T. Boecking

This study uses single-molecule fluorescence imaging to analyze the kinetics of PFO pore formation, revealing that membrane insertion is kinetically controlled.

bioRxiv · Oct 19, 2021Biophysics