M. Christie

Parallel genetic adaptation amidst a background of changing effective population sizes in divergent yellow perch (Perca flavescens) populations

The paper uses genome-wide data to analyze demographic histories and genetic adaptation in two yellow perch populations, finding increased effective population sizes and parallel adaptation to reduced visual clarity.

Long distance avian migrants fail to bring 2.3.4.4b HPAI H5N1 into Australia for a second year in a row

The paper reports the continued absence of HPAI H5N1 lineage 2.3.4.4b and antibodies against it in migratory birds in Australia during October-December 2023.

Brief report: Reclassifying SCLC-Y as SMARCA4 deficient malignancies - resolving the controversy

The paper reclassifies YAP1-expressing SCLC-Y as SMARCA4-deficient malignancies, showing they lack SCLC features and instead resemble SMARCA4-deficient tumors.

Single-molecule analysis of the entire perfringolysin O poreformation pathway

This study uses single-molecule fluorescence imaging to analyze the kinetics of PFO pore formation, revealing that membrane insertion is kinetically controlled.

Molecular basis for GIGYF-TNRC6 complex assembly in miRNA-mediated translational repression

This study determines the crystal structures of GIGYF1/2 GYF domains interacting with TNRC6 proteins, revealing how they bridge 4EHP to miRNA targets for translational repression.

Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein using mRNA Display

The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.

Rapid resistance to pesticide control is predicted to evolve in an invasive fish

The paper models the evolution of pesticide resistance in sea lamprey and finds resistance alleles can fixate within 40-80 years of pesticide use despite long generation times.

Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.

This paper develops an intravenous pentamidine formulation using Pluronic micelles to enhance CNS exposure for stage 2 HAT treatment, finding no major neurotoxicity but limited BBB penetration enhancement.

PI3K Activation In Neural Stem Cells Drives Tumorigenesis Which Can Be Suppressed By Targeting CREB

This study shows that PI3K pathway activation in neural stem cells initiates tumorigenesis, and targeting CREB reduces tumor growth in a mouse model of high-grade glioma.