Author

S. H. Mueller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. M. van Oijen· 3 shared L. M. Spenkelink· 3 shared A. D. Griffiths· 1 shared A. Pichard-Kostuch· 1 shared A. Shirbini· 1 shared C. Kay· 1 shared C. Maher· 1 shared C. Mc Guinness· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

A. M. van Oijen

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3 papers

Recent·Most cited

Optimised Nanobody-based Quenchbodies for Enhanced Protein Detection

J. H. Cater, N. Elsalamouny, G. H. Mansour, S. Hutchinson, C. Mc Guinness, S. H. Mueller, R. R. Spinks, N. Shanmugam, A. Pichard-Kostuch, V. Zahoransky, H. Ghodke, M. Ribezzi-Crivellari, H. Yu, A. M. van Oijen, A. D. Griffiths, L. M. Spenkelink

This study optimizes nanobody-based quenchbodies for enhanced protein detection, achieving fluorescence increases of 1.5-2.4-fold and detecting IL-6 down to 2 nM.

bioRxiv · Mar 27, 2024Bioengineering

Rapid single-molecule characterisation of nucleic-acid enzymes

S. H. Mueller, L. J. Fitschen, A. Shirbini, S. M. Hamdan, L. M. Spenkelink, A. M. van Oijen

This paper introduces a single-molecule assay to rapidly characterize DNA metabolism enzymes by measuring fluorescence intensity changes during DNA synthesis, unwinding, or digestion.

bioRxiv · Mar 3, 2022Biophysics

Tunability of DNA polymerase stability during eukaryotic DNA replication

J. S. Lewis, L. M. Spenkelink, G. D. Schauer, O. Yurieva, S. H. Mueller, V. Natarajan, G. Kaur, C. Maher, C. Kay, M. E. O'Donnell, A. M. van Oijen

The paper shows how DNA polymerase stability and exchange dynamics in the yeast replisome are tuned by local concentrations, enabling efficient replication and adaptation to genomic challenges.

bioRxiv · Jun 7, 2019Biophysics