C. Moresi

Quantifying the varying harvest of fermentation products from the human gut microbiota

The paper quantifies the metabolic flux of fermentation products from the gut microbiota, showing it varies with diet but not microbiota composition.

Targeted induction of gut-microbial metabolism acutely affects feeding patterns and clock gene expression in the host

This study shows that increasing gut microbial metabolism in mice affects host clock gene expression and reduces food intake beyond microbial calorie contribution.

A rationally designed inactivated Salmonella Typhimurium vaccine induces strong and long-lasting immune responses in pigs

This study evaluates an inactivated Salmonella Typhimurium vaccine in pigs, showing strong and long-lasting immune responses with improved safety and seroconversion compared to live vaccines.

Microbiota colonization tunes the antigen threshold of microbiota-specific T cell activation in the gut

This study shows that microbiota colonization affects T cell activation thresholds in the gut, with immune system status and TCR specificity influencing responses to colonizing bacteria.

Vaccine-enhanced competition permits rational bacterial strain replacement in the gut

The paper demonstrates that oral vaccination combined with engineered competitor strains can exclude pathogens and replace bacterial strains in the mouse gut.

Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide is dependent on the resident microbiota

This study quantifies colonization bottlenecks and growth dynamics of Bacteroides thetaiotaomicron in the gut, showing that capsular polysaccharide provides a fitness advantage dependent on microbiota composition.