Author

C. Patinios

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:genome assembly· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. van der Oost· 3 shared R. Staals· 2 shared A. Arifah· 1 shared A. Bardis· 1 shared A. Barendrecht· 1 shared A. M. Amieiro· 1 shared A. M. Lopez-Contreras· 1 shared B. Perez· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

J. van der Oost

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Type III-B CRISPR-Cas signaling-based cascade of proteolytic cleavages

J. Steens, J. P. Bravo, C. R. P. Salazar, C. Yildiz, A. M. Amieiro, S. Kostlbacher, S. H. P. Prinsen, C. Patinios, A. Bardis, A. Barendrecht, R. A. Scheltema, T. J. G. Ettema, J. van der Oost, D. W. Taylor, R. Staals

This study characterizes a type III-B CRISPR-Cas system in Haliangium ochraceum, revealing a proteolytic cascade involving SAVED-CHAT and PCaspase that activates immune responses against RNA targets.

bioRxiv · Jun 23, 2023 · PreprintBiochemistry

Multiplex genome engineering in Clostridium beijerinckii NCIMB 8052 using CRISPR-Cas12a

C. Patinios, S. T. de Vries, M. Diallo, L. Lanza, P. L. J. V. Q. Verbrugge, A. M. Lopez-Contreras, J. van der Oost, R. A. Weusthuis, S. W. M. Kengen

This paper develops a CRISPR-Cas12a system for efficient genome engineering in Clostridium beijerinckii NCIMB 8052, achieving single-gene knockouts and multiplex editing.

bioRxiv · Aug 22, 2022 · PreprintMicrobiology

SIBR-Cas enables host-independent and universal CRISPR genome engineering in bacteria

C. Patinios, S. Creutzburg, A. Arifah, B. Perez, C. Ingham, S. Kengen, J. van der Oost, R. Staals

This paper introduces SIBR-Cas, a CRISPR-based genome engineering tool that works universally in bacteria without host factors or exogenous recombinases, enabling gene knockouts in species with poor homologous recombination.

bioRxiv · Apr 26, 2021Bioengineering