Author

C. K. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

G. Rancati· 3 shared M. Giam· 2 shared A. Chudnovskiy· 1 shared A. Gopalan· 1 shared A. H. Rahman· 1 shared A. J. Awad· 1 shared A. Kamarulzaman· 1 shared A. Maayan· 1 shared

Activity by Year

2019-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersCancer Biology

G. Rancati

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Whole-genome duplication shapes the aneuploidy landscape of human cancers

K. Prasad, M. Bloomfield, H. Levi, K. Keuper, S. V. Bernhard, N. C. Baudoin, G. Leor, M. Giam, C. K. Wong, G. Rancati, Z. Storchova, D. Cimini, U. Ben-David

This study shows that whole-genome duplication (WGD) alters aneuploidy patterns in human cancers, leading to distinct recurrence and genetic interaction patterns between WGD- and WGD+ tumors.

bioRxiv · May 5, 2021Cancer Biology

SARS-CoV-2 lineage B.6 is the major contributor to transmission in Malaysia

Y. M. Chong, I.-C. Sam, J. Chong, M. Kahar Bador, S. Ponnampalavanar, S. F. Syed Omar, A. Kamarulzaman, V. Munusamy, C. K. Wong, F. H. Jamaluddin, Y. F. Chan

This study analyzes SARS-CoV-2 genome sequences from Malaysia to show that lineage B.6 became the dominant cause of community transmission following a religious mass gathering, with global implications.

PLOS Neglected Tropical Diseases · Nov 30, 2020Peer-reviewedMicrobiology

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilities

F. Tang, S. Wang, C. K. Wong, C. J. Lee, S. Cohen, J. Park, C. E. Hill, K. Eng, R. Bareja, T. Han, E. M. Liu, A. Palladino, W. Di, D. Gao, W. Abida, , E. Khurana

This study identifies four subtypes of castration-resistant prostate cancer using ATAC-seq and RNA-seq data, revealing novel therapeutic targets and classification for 370 patients.

bioRxiv · Oct 26, 2020 · PreprintCancer Biology

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

S. Giunta, S. Herve, R. R. White, T. Wilhelm, M. Dumont, A. Scelfo, R. Gamba, C. K. Wong, G. Rancati, A. Smogorzewska, H. Funabiki, D. Fachinetti

This study shows that CENP-A chromatin prevents replication stress at centromeres, reducing structural aneuploidy by safeguarding DNA replication of alpha-satellite repeats.

bioRxiv · Sep 1, 2020Cell Biology

Characterization of Stanniocalcin-1 Expression in Macrophage Differentiation

C. K. Wong, C. C. Leung

This study investigates STC1 expression during macrophage differentiation, showing its association with M1 polarization and its role in regulating inflammation through extracellular vesicles.

bioRxiv · May 18, 2020Cell Biology

p53 induces senescence in the unstable progeny of aneuploid cells

G. Rancati, M. Giam, C. K. Wong, J. S. Low, M. Sinelli, O. Dreesen

The paper shows that p53 induces senescence in the chromosomally unstable progeny of aneuploid cells, limiting their proliferation and reducing heterogeneity in aneuploid populations.

bioRxiv · Oct 25, 2019Cancer Biology

Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular Events

D. M. Fernandez, A. H. Rahman, N. Fernandez, A. Chudnovskiy, E.-a. D. Amir, L. Amadori, N. S. Khan, C. K. Wong, R. Shamailova, C. Hill, Z. Wang, R. Remark, J. R. Li, C. Pina, C. Faries, , C. Giannarelli

The paper identifies immune dysregulations in atherosclerotic plaques linked to ischemic cerebrovascular events using single-cell analyses of T cells and macrophages.

bioRxiv · Aug 2, 2019 · PreprintImmunology