A. H. Rahman

Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

The paper identifies two CAF subsets in human lung tumors that promote T cell exclusion through distinct matrix programs and spatial organization.

Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery

This study identifies shifts in lung macrophage composition linked to COVID-19 severity and recovery, suggesting therapeutic strategies targeting macrophage function.

Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor immune composition

Perturb-map enables spatial CRISPR screening in tumors, identifying genes that regulate immune composition by mapping gene knockouts and their effects on the tumor microenvironment.

Multimodal Single-Cell Characterization of the Human Granulocyte Lineage

This study uses multi-modal CITE-seq to accurately characterize human granulocytes, showing higher transcript detection with BD Rhapsody compared to 10X Genomics.

Donor-Specific Plasma Factors Contribute to Aberrant Staining Artifacts with a Commercial Lyophilized Mass Cytometry Antibody Panel

The paper identifies donor-specific plasma factors causing aberrant staining in a commercial CyTOF antibody panel and proposes mitigation strategies.

CITEseq analysis of non-small-cell lung cancer lesions reveals an axis of immune cell activation associated with tumor antigen load and TP53 mutations

The paper analyzes CITEseq data from NSCLC lesions to identify an immune cell activation module linked to tumor antigen load and TP53 mutations.

Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular Events

The paper identifies immune dysregulations in atherosclerotic plaques linked to ischemic cerebrovascular events using single-cell analyses of T cells and macrophages.

Development of a Comprehensive Antibody Staining Database using a Standardized Analytics Pipeline

The paper develops a standardized workflow for mass cytometry data analysis and presents an antibody staining database with insights into immune cell markers and fixation effects.