C. R. Armbruster

Lytic bacteriophages interact with respiratory epithelial cells and induce the secretion of antiviral and proinflammatory cytokines

This study investigates how lytic bacteriophages interact with respiratory epithelial cells and their effects on cytokine secretion, highlighting the need to consider mammalian responses in phage therapy.

Pseudomonas aeruginosa senses and responds to epithelial potassium flux via Kdp operon to promote biofilm biogenesis

This study shows Pseudomonas aeruginosa uses potassium efflux from human airway epithelial cells to enhance biofilm formation through the KdpFABCDE system.

Low diversity and instability of the sinus microbiota over time in adults with cystic fibrosis

This study examines the microbiota of adults with cystic fibrosis (CF) and finds low diversity and instability in sinus microbial communities, linked to inflammation and worse sinus disease.

Evolution and adaptation of Pseudomonas aeruginosa in the paranasal sinuses of people with cystic fibrosis

This study identifies three evolutionary genetic routes of Pseudomonas aeruginosa adaptation in the sinuses of people with cystic fibrosis, suggesting sinuses may be an early site of pathoadaptation before lung infections.

Phenotypic differences in reversible attachment behavior reveal distinct P. aeruginosa surface colonization strategies

The paper examines reversible attachment behavior in P. aeruginosa strains PAO1 and PA14, revealing distinct surface colonization strategies through single-cell tracking and stochastic modeling.

Heterogeneity in surface sensing produces a division of labor in Pseudomonas aeruginosa populations

This study shows that Pseudomonas aeruginosa develops two subpopulations with distinct c-di-GMP levels after surface attachment, leading to a division of labor in biofilm formation and surface exploration.