Author

C. K. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. L. Gomez· 2 shared C. Specht· 2 shared G. C. L. Wong· 2 shared S. M. Levitz· 2 shared S. Webster· 2 shared A. Abraham· 1 shared A. Akalin· 1 shared A. M. Hinze· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

C. L. Gomez

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Dysregulated Pulmonary Inflammatory Responses Exacerbate the Outcome of Secondary Aspergillosis Following Influenza

C. K. Lee, L. V. N. Oliveira, A. Akalin, C. Specht, D. Lourenco, C. L. Gomez, Z. G. Ramirez-Ortiz, J. P. Wang, S. M. Levitz

This study shows that superinfected mice with influenza and Aspergillus fumigatus have higher mortality during early influenza stages due to dysregulated inflammation, not increased fungal growth.

bioRxiv · Jun 27, 2023Immunology

Phylogenetic analysis of human parainfluenza type 3 virus strains responsible for the outbreak during the COVID-19 pandemic in Seoul, South Korea

H. N. Kim, S. Y. Yoon, C. S. Lim, C. K. Lee, J. Yoon

The paper analyzes HPIV3 strains from a Seoul outbreak, finding a new genetic cluster within subcluster C3 with unique amino acid substitutions.

bioRxiv · Mar 15, 2022Microbiology

Protection of mice against experimental cryptococcosis by synthesized peptides delivered in glucan particles

C. Specht, E. J. Homan, C. K. Lee, Z. Mou, C. L. Gomez, M. M. Hester, A. Abraham, F. Rus, G. Ostroff, S. M. Levitz

The paper shows that glucan particle-based vaccines containing specific peptides from C. neoformans proteins can protect mice against cryptococcosis, with varying efficacy depending on the peptide and mouse strain.

bioRxiv · Nov 12, 2021Immunology

Force-induced changes of PilY1 drive surface sensing by Pseudomonas aeruginosa

S. Webster, M. Mathelie-Guinlet, A. Verissimo, D. Schultz, A. Viljoen, C. K. Lee, W. C. Schmidt, G. Wong, Y. Dufrene, G. OToole

This study shows that force-induced conformational changes in PilY1, a TFP tip protein, are required for surface sensing in Pseudomonas aeruginosa, affecting c-di-GMP signaling and biofilm formation.

bioRxiv · Aug 24, 2021Microbiology

Fine tuning cyclic-di-GMP signaling in Pseudomonas aeruginosa using the type 4 pili alignment complex

S. Webster, C. K. Lee, W. Schmidt, G. C. L. Wong, G. O'Toole

This paper identifies PilO's role in modulating SadC activity to regulate cyclic-di-GMP levels and biofilm formation in Pseudomonas aeruginosa.

bioRxiv · Oct 17, 2020 · PreprintMicrobiology

Heterogeneity in surface sensing produces a division of labor in Pseudomonas aeruginosa populations

C. R. Armbruster, C. K. Lee, J. Parker-Gilham, J. de Anda, A. Xia, B. S. Tseng, L. R. Hoffman, F. Jin, C. Harwood, G. C. L. Wong, M. R. Parsek

This study shows that Pseudomonas aeruginosa develops two subpopulations with distinct c-di-GMP levels after surface attachment, leading to a division of labor in biofilm formation and surface exploration.

bioRxiv · Jan 29, 2019Microbiology

Microbial biogeography of 1,000 geothermal springs in New Zealand

J. F. Power, C. R. Carere, C. K. Lee, G. L. Wakerley, D. W. Evans, M. Button, D. White, M. D. Climo, A. M. Hinze, X. C. Morgan, I. R. McDonald, S. C. Cary, M. B. Stott

This study analyzes microbial communities in 1,019 geothermal springs across New Zealand to identify factors influencing biogeographical patterns, finding pH as the primary driver of diversity and two dominant genera shaping community composition.

bioRxiv · Jan 15, 2018Microbiology