Author

C. Redfield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 5 Approach:experimental assay· 4 Assay:protein structure· 3 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

D. A. I. Mavridou· 2 shared L. S. Stelzl· 2 shared S. J. Ferguson· 2 shared A. Baldwin· 1 shared A. J. Baldwin· 1 shared A. J. Costa-Filho· 1 shared A. R. Mehdipour· 1 shared A. Watts· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

D. A. I. Mavridou

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6 papers

Recent·Most cited

The transition state for coupled folding and binding of a disordered DNA binding domain resembles the unbound state

M. Kuravsky, C. F. Kelly, C. Redfield, S. L. Shammas

This study examines the transition state of DNA binding in disordered bZIP domains and finds it resembles the unbound state, challenging predictions of disorder-mediated rate enhancement.

bioRxiv · Feb 12, 2024Biophysics

Molecular determinants of dynamic protein-protein interactions in the functional cycle of the membrane protein DsbD

L. S. Stelzl, P. Kritsiligkou, A. R. Mehdipour, A. J. Baldwin, S. J. Ferguson, D. A. I. Mavridou, M. S. P. Sansom, C. Redfield

This study identifies molecular determinants of dynamic protein-protein interactions in DsbD using NMR, molecular dynamics, and AlphaFold modeling, revealing redox-state-dependent binding and a putative thioredoxin binding site.

bioRxiv · Sep 7, 2022 · PreprintBiophysics

Structural characterisation of KKT4, an unconventional microtubule-binding kinetochore protein

P. Ludzia, E. Lowe, G. Marciano, S. Mohammed, C. Redfield, B. Akiyoshi

This study characterizes the structure and dynamics of KKT4, a kinetoplastid kinetochore protein, revealing its microtubule-binding domain and DNA-binding properties.

bioRxiv · Oct 14, 2020Cell Biology

Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

L. S. Stelzl, D. A. I. Mavridou, E. Saridakis, D. Gonzalez, A. Baldwin, S. J. Ferguson, M. Sansom, C. Redfield

This study shows how oxidation of cysteine thiols to a disulfide bond in DsbD introduces local frustration, disrupting the cap-loop structure and enabling loop opening during its catalytic cycle.

bioRxiv · Jun 14, 2020Biophysics

Pal stabilises the bacterial outer membrane during constriction by a mobilisation-and-capture mechanism

J. Szczepaniak, P. Holmes, K. Rajasekar, R. Kaminska, F. Samsudin, P. G. Inns, P. Rassam, S. Khalid, S. M. Murray, C. Redfield, C. Kleanthous

The paper shows the Tol system in E. coli actively mobilizes and captures Pal to coordinate outer membrane constriction with cell division.

bioRxiv · Oct 4, 2019 · PreprintMicrobiology

Conformational flexibility of GRASP protein and its constituent PDZ subdomains reveals structural basis of its promiscuous interactome

L. F. S. Mendes, M. R. B. Batista, P. J. Judge, A. Watts, C. Redfield, A. J. Costa-Filho

This paper investigates the structural flexibility of GRASP PDZ domains and explains their promiscuous interactome through biophysical analysis.

bioRxiv · Jun 10, 2019Biophysics