Author

A. R. Mehdipour

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:mechanistic / dynamical model· 3 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

G. Hummer· 3 shared S. Welsch· 2 shared A. Ejima· 1 shared A. J. Baldwin· 1 shared A. Schmidt· 1 shared B. Gasnier· 1 shared C. Debacker· 1 shared C. Low· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersMicrobiology

G. Hummer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes

K. E. J. Jungnickel, O. Guelle, M. Iguchi, W. Dong, V. Kotov, F. Gabriel, C. Debacker, J. Dairou, I. McCort-Tranchepain, N. N. Laqtom, S. H. Chan, A. Ejima, K. Sato, D. Massa Lopez, P. Saftig, , M. Damme

The paper identifies MFSD1 as a lysosomal dipeptide uniporter that facilitates the transport of cationic and neutral dipeptides when amino acid exporters are overloaded.

Nature Cell Biology · Jun 5, 2024Peer-reviewedBiochemistry

Molecular determinants of dynamic protein-protein interactions in the functional cycle of the membrane protein DsbD

L. S. Stelzl, P. Kritsiligkou, A. R. Mehdipour, A. J. Baldwin, S. J. Ferguson, D. A. I. Mavridou, M. S. P. Sansom, C. Redfield

This study identifies molecular determinants of dynamic protein-protein interactions in DsbD using NMR, molecular dynamics, and AlphaFold modeling, revealing redox-state-dependent binding and a putative thioredoxin binding site.

bioRxiv · Sep 7, 2022 · PreprintBiophysics

Dissecting the conformational complexity and flipping mechanism of a prokaryotic heme transporter

D. Wu, A. R. Mehdipour, F. Finke, H. G. Goojani, R. R. Groh, T. N. Grund, T. M. Reichhart, R. Zimmermann, S. Welsch, D. Bald, M. Shepherd, G. Hummer, S. Safarian

The paper identifies CydDC as a heme flippase essential for cytochrome bd maturation, revealing its conformational mechanism through cryo-EM and molecular dynamics.

bioRxiv · Apr 7, 2022 · PreprintMicrobiology

Cryo-EM structures of pentameric autoinducer-2 exporter from E. coli reveal its transport mechanism

R. Khera, A. R. Mehdipour, J. R. Bolla, J. Kahnt, S. Welsch, U. Ermler, C. Muenke, C. V. Robinson, G. Hummer, H. Xie, H. Michel

The paper reports cryo-EM structures of AI-2 exporters from E. coli, revealing their pentameric structure and elevator-type transport mechanism.

bioRxiv · Oct 20, 2021 · PreprintBiophysics

Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter

E. Lambert, A. R. Mehdipour, A. Schmidt, G. Hummer, C. Perez

This study investigates the mechanism of LtaA, a proton-dependent MFS lipid transporter, revealing a trap-and-flip mechanism for lipid translocation.

bioRxiv · Aug 5, 2021Biochemistry