K. Haendler

Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

Donor tissue-resident memory-like T and NK cells generate a transient peripheral chimerism in lung transplant recipients, potentially protective from chronic lung allograft dysfunction

Donor TRM-like T and NK cells create a temporary chimerism in lung transplant recipients, possibly reducing the risk of chronic lung allograft dysfunction.

Salmonella succinate utilisation is inhibited by multiple regulatory systems

This study identifies multiple RpoS-independent regulatory systems that inhibit Salmonella's succinate utilisation, revealing redundant mechanisms controlling carbon metabolism during infection.

Single-cell analysis reveals dynamics of human B cell differentiation and identifies novel B and antibody-secreting cell intermediates

The paper uses single-cell RNA sequencing to study human B cell differentiation, identifying novel intermediates and a germinal-center-like population in vitro.

Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

This study identifies Apolipoprotein E's role in Dectin-1-dependent development of monocyte-derived alveolar macrophages during pulmonary β-glucan-induced inflammation.

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.

This study identifies aberrant paracrine signaling between osteoprogenitors and osteoclasts driven by H3.3 mutations as a mechanism underlying giant cell tumor of bone and its response to treatment.

A rule-based data-informed cellular consensus map of the human mononuclear phagocyte cell space

The paper develops a rule-based data-informed approach to create a consensus map of the human mononuclear phagocyte cell space using computational integration and single-cell RNA-sequencing.