Pyruvate kinase controls signal strength in the insulin secretory pathway
S. L. Lewandowski, R. L. Cardone, H. R. Foster, T. Ho, E. Potapenko, C. Poudel, H. R. VanDeusen, T. C. Alves, X. Zhao, M. E. Capozzi, I. Jahan, C. S. Nunemaker, J. E. Campbell, C. J. Thomas, R. G. Kibbey, M. J. Merrins
This paper shows pyruvate kinase (PK) controls insulin secretion by regulating ATP/ADP ratios and mitochondrial metabolism in beta-cells, suggesting PK activation as a potential diabetes therapy.
bioRxiv · Jan 15, 2020Cell Biology