Author

T. C. Alves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

M. J. Merrins· 2 shared R. G. Kibbey· 2 shared R. L. Cardone· 2 shared S. L. Lewandowski· 2 shared X. Zhao· 2 shared A. Abdollahi· 1 shared A. Abulizi· 1 shared A. Chalfun-Junior· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersPhysiology

M. J. Merrins

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Unveiling the phenology and associated floral regulatory pathways of Humulus lupulus L. in subtropical conditions

R. M. Gutierrez, R. R. de Oliveira, T. H. C. Ribeiro, K. K. P. de Oliveira, J. V. N. Silva, T. C. Alves, L. R. do Amaral, M. d. S. Gomes, M. d. S. Gomes, A. Chalfun-Junior

This study investigates the phenology and floral regulatory pathways of hops in subtropical conditions, finding that reproductive transition is primarily controlled by endogenous factors rather than photoperiod.

bioRxiv · Sep 15, 2023 · PreprintPlant Biology

GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy

A. Mukha, U. Kahya, A. Linge, O. Chen, S. Lock, V. Lukiyanchuk, S. Richter, T. C. Alves, M. Peitzsch, V. Telychko, S. Skvortsov, G. Negro, B. Aschenbrenner, I.-I. Skvortsova, P. Mirtschink, , A. Dubrovska

This study shows that glutamine catabolism via GLS regulates redox state, stemness, and autophagy in prostate cancer, affecting radiosensitivity and patient outcomes.

bioRxiv · Jan 7, 2021Cancer Biology

Pharmacologic activation of the mitochondrial phosphoenolpyruvate cycleenhances islet function in vivo

A. Abulizi, R. Stark, R. L. Cardone, S. L. Lewandowski, X. Zhao, T. C. Alves, C. Thomas, C. Kung, B. Wang, S. Siebel, Z. B. Andrews, M. J. Merrins, R. G. Kibbey

This study shows that pharmacologic activation of pyruvate kinase (PK) enhances insulin secretion in preclinical diabetes models by stimulating the mitochondrial phosphoenolpyruvate (PEP) cycle.

bioRxiv · Feb 13, 2020 · PreprintPhysiology

Pyruvate kinase controls signal strength in the insulin secretory pathway

S. L. Lewandowski, R. L. Cardone, H. R. Foster, T. Ho, E. Potapenko, C. Poudel, H. R. VanDeusen, T. C. Alves, X. Zhao, M. E. Capozzi, I. Jahan, C. S. Nunemaker, J. E. Campbell, C. J. Thomas, R. G. Kibbey, M. J. Merrins

This paper shows pyruvate kinase (PK) controls insulin secretion by regulating ATP/ADP ratios and mitochondrial metabolism in beta-cells, suggesting PK activation as a potential diabetes therapy.

bioRxiv · Jan 15, 2020Cell Biology