Author

C. X.- Q. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:clustering· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

E. A. Fon· 3 shared I. Shlaifer· 2 shared M.-F. Dorion· 2 shared T. M. Durcan· 2 shared W. Luo· 2 shared A. MacDonald· 1 shared A. Muraleedharan· 1 shared A. Wallis· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

E. A. Fon

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Author profile →

3 papers

Recent·Most cited

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

B. Vanderperre, A. Muraleedharan, M.-F. Dorion, F. Larroquette, E. Del Cid Pellitero, N. Rajakulendran, C. X.- Q. Chen, R. Lariviere, C. Michaud-Tardif, R. Chidiac, D. Lipuma, G. Macleod, R. Thomas, Z. Wang, W. E. Reintsch, , E. A. Fon

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

bioRxiv · Sep 29, 2023 · PreprintCell Biology

MerTK mediates the immunologically silent uptake of alpha-synuclein fibrils by human microglia

M.-F. Dorion, K. Senkevich, M. Yaqubi, N. W. Kieran, C. X.- Q. Chen, A. MacDonald, W. Luo, A. Wallis, I. Shlaifer, J. Hall, R. W. R. Dudley, I. A. Glass, Birth Defects Research Laboratory, J. A. Straton, E. A. Fon, , L. M. Healy

This study shows MerTK mediates microglial uptake of alpha-synuclein fibrils without triggering inflammation and links MERTK variants to Parkinson's disease.

bioRxiv · Mar 4, 2023 · PreprintCell Biology

Standardized quality control workflow to evaluate the reproducibility and differentiation potential of human iPSCs into neurons

C. X.- Q. Chen, N. Abdian, G. Maussion, R. A. Thomas, I. Demirova, E. Cai, M. Tabatabaei, L. K. Beitel, J. Karamchandani, E. A. Fon, T. M. Durcan

The paper establishes a standardized quality control workflow to assess variability and reproducibility of human iPSCs in differentiation into neurons and other germ layers.

bioRxiv · Jan 13, 2021 · PreprintCell Biology