Author

N. Rajakulendran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. Macleod· 3 shared S. Angers· 3 shared Z. Steinhart· 2 shared A. H. Luchman· 1 shared A. Muraleedharan· 1 shared A. Nikolic· 1 shared A. Yang· 1 shared B. Gordon· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

G. Macleod

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

B. Vanderperre, A. Muraleedharan, M.-F. Dorion, F. Larroquette, E. Del Cid Pellitero, N. Rajakulendran, C. X.- Q. Chen, R. Lariviere, C. Michaud-Tardif, R. Chidiac, D. Lipuma, G. Macleod, R. Thomas, Z. Wang, W. E. Reintsch, , E. A. Fon

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

bioRxiv · Sep 29, 2023 · PreprintCell Biology

Paridiprubart inhibits TLR4-dependant NF-κB activation by multiple pathogens

R. Malty, R. Hilbe, S. Ahn, L. Kesselman, J. Lam, K. Kasawara, L. Costa, N. Rajakulendran, B. Gordon, M. Brooks, S. Mubareka, I. Tancevski, S. D. Gray-Owen

This study shows that paridiprubart, a TLR4 inhibitor, suppresses NF-κB activation by multiple pathogens including SARS-CoV-2 and bacterial agents.

bioRxiv · Jun 27, 2023 · PreprintImmunology

The Mediator tail module cooperates with proneural factors to determine fate identity in Glioblastoma.

M. Ahmadi, G. MacLeod, N. Rajakulendran, M. Kosic, A. Yang, F. Molaei, S. Lin, Z. Steinhart, N. I. Park, P. B. Dirks, S. Angers

The paper identifies MED24 and MED25 as essential for ASCL1-mediated neuronal differentiation in GSCs and other cell types, revealing a role for the Mediator tail module in this process.

bioRxiv · May 4, 2021 · PreprintCell Biology

Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival

P. Guilhamon, M. M. Kushida, A. Nikolic, D. Singhal, G. MacLeod, S. A. M. Tonekaboni, F. M. Cavalli, C. Arlidge, N. Rajakulendran, N. Rastegar, X. Hao, R. Hassam, L. J. Smith, H. Whetstone, F. J. Coutinho, , M. Lupien

The paper uses single-cell chromatin accessibility to identify distinct glioblastoma stem cell states predictive of patient survival.

bioRxiv · Mar 13, 2020 · PreprintCancer Biology