Author

D. Lipuma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

D. Lechardeur· 2 shared P. Arnoux· 2 shared V. Saillant· 2 shared A. Boussac· 1 shared A. Muraleedharan· 1 shared B. Vanderperre· 1 shared C. Michaud-Tardif· 1 shared C. X.- Q. Chen· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

D. Lechardeur

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

B. Vanderperre, A. Muraleedharan, M.-F. Dorion, F. Larroquette, E. Del Cid Pellitero, N. Rajakulendran, C. X.- Q. Chen, R. Lariviere, C. Michaud-Tardif, R. Chidiac, D. Lipuma, G. Macleod, R. Thomas, Z. Wang, W. E. Reintsch, , E. A. Fon

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

bioRxiv · Sep 29, 2023 · PreprintCell Biology

HssS activation by membrane heme defines a paradigm for 2-component system signaling in Staphylococcus aureus.

D. Lechardeur, V. Saillant, L. Morey, D. Lipuma, P. Boëton, P. Arnoux

This study identifies how heme binds to the HssS sensor in Staphylococcus aureus, triggering a signaling cascade that activates heme efflux to prevent toxicity.

bioRxiv · Nov 3, 2022 · PreprintMicrobiology

A novel Enterococcus faecalis heme transport regulator (FhtR) is a heme sensor in the gastrointestinal tract.

V. Saillant, D. Lipuma, E. Ostyn, L. Joubert, A. Boussac, H. Guerin, G. Brandelet, P. Arnoux, D. Lechardeur

This paper identifies FhtR as a heme sensor in E. faecalis that regulates heme homeostasis by controlling an efflux pump and catalase expression in the gastrointestinal tract.

mBio · Feb 23, 2021Peer-reviewedMicrobiology