Author

C.-H. Shen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Organism:mouse· 2 Approach:deep learning· 1 Organism:non-human primate· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

P. D. Kwong· 4 shared R. Rawi· 3 shared T. Zhou· 3 shared Y. Tsybovsky· 3 shared A. S. Olia· 2 shared B. Zhang· 2 shared G.-Y. Chuang· 2 shared I.-T. Teng· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

P. D. Kwong

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Author profile →

5 papers

Recent·Most cited

In Silico Improvement of Highly Protective Anti-Malarial Antibodies

M. Mateo, P. Tripathi, L. Da Silva Pereira, P. Kiyuka, T. Liu, B. Zhang, Y. Yang, B. G. Bonilla, M. Dillon, M. Lee, C.-H. Shen, A. Schon, S. Kratochvil, F. D. Batista, A. H. Idris, , R. Rawi

The paper improves an anti-malarial antibody using an in silico pipeline, resulting in a variant with higher binding affinity and better malaria protection.

bioRxiv · Apr 8, 2022 · PreprintImmunology

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

W. Shi, L. Wang, T. Zhou, M. Sastry, E. S. Yang, Y. Zhang, M. Chen, X. Chen, M. Choe, A. Creanga, K. Leung, A. S. Olia, A. Pegu, R. Rawi, C.-H. Shen, , P. D. Kwong

This paper identifies an antibody, WS6, from a mouse immunized with SARS-CoV-2 spike mRNA, which neutralizes diverse beta-coronaviruses by targeting a conserved helical epitope on the S2 subunit.

bioRxiv · Jan 25, 2022Immunology

Paired heavy and light chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses

B. B. Banach, G. Cerutti, A. S. Fahad, C.-H. Shen, M. Oliveira de Souza, P. S. Katsamba, Y. Tsybovsky, P. Wang, M. S. Nair, Y. Huang, I. M. Francino Urdaniz, P. J. Steiner, M. Gutierrez-Gonzalez, L. Liu, S. N. Lopez Acevedo, , B. J. DeKosky

This study identifies a public antibody class, IGHV3-53/3-66, with potent SARS-CoV-2 neutralization capabilities through paired heavy and light chain interactions.

bioRxiv · Dec 31, 2020Immunology

Impact of glycan positioning on HIV-1 Env glycan shield density, function, and antibody recognition

Q. Wei, A. A. Harget, B. Knoppova, A. Duverger, R. Ravi, C.-H. Shen, S. K. Farney, S. Hall, R. Brown, B. F. Keele, S. L. Heath, M. S. Saag, O. Kutsch, G.-Y. Chuang, P. D. Kwong, , J. Novak

This study shows how changes in individual glycan units of HIV-1 Env affect structure, function, and antibody recognition through high-resolution glycomics and molecular dynamics.

bioRxiv · Mar 31, 2020Microbiology

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

K. Xu, P. Acharya, R. Kong, C. Cheng, G.-Y. Chuang, K. Liu, M. K. Louder, S. O Dell, R. Rawi, M. Sastry, C.-H. Shen, B. Zhang, T. Zhou, M. Asokan, R. T. Bailer, , McDermott

This study shows that targeting the HIV-1 fusion peptide with specific immunogens induces cross-clade neutralizing antibodies in animals.

bioRxiv · Apr 23, 2018Immunology