Author

A. H. Idris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:clustering· 2 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

R. A. Seder· 5 shared H. J. Sutton· 3 shared I. A. Cockburn· 3 shared A. Schon· 2 shared B. J. Flynn· 2 shared D. Chatterjee· 2 shared K. E. Lyke· 2 shared M. Dillon· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersImmunology

R. A. Seder

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5 papers

Recent·Most cited

Plasma cells are formed in waning germinal centers via an affinity-independent process

H. J. Sutton, B. J. Parker, M. Lofgren, C. Dacon, D. Chatterjee, X. Gao, H. G. Kelly, R. A. Seder, J. Tan, A. H. Idris, T. Neeman, I. A. Cockburn

The paper tracks Ighg2A10 cells in germinal centers using single-cell RNA-seq and finds that plasma cells form in waning GCs through an affinity-independent process.

bioRxiv · Apr 13, 2023 · PreprintImmunology

In Silico Improvement of Highly Protective Anti-Malarial Antibodies

M. Mateo, P. Tripathi, L. Da Silva Pereira, P. Kiyuka, T. Liu, B. Zhang, Y. Yang, B. G. Bonilla, M. Dillon, M. Lee, C.-H. Shen, A. Schon, S. Kratochvil, F. D. Batista, A. H. Idris, , R. Rawi

The paper improves an anti-malarial antibody using an in silico pipeline, resulting in a variant with higher binding affinity and better malaria protection.

bioRxiv · Apr 8, 2022 · PreprintImmunology

The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

L. T. Wang, N. K. Hurlburt, A. Schon, B. J. Flynn, L. S. Pereira, M. Dillon, Y. Flores-Garcia, B. Bonilla, F. Zavala, A. H. Idris, J. R. Francica, M. Pancera, R. A. Seder

This study shows that the L9 antibody's light chain is essential for binding PfCSP minor repeats and enhancing neutralization of malaria sporozoites.

bioRxiv · Aug 11, 2021Immunology

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

H. J. Sutton, R. Aye, A. H. Idris, R. Vistein, E. Nduati, O. Kai, J. Mwacharo, L. Xi, X. Gao, D. Andrews, M. Koutsakos, T. H. O. Nguyen, M. Nekrasov, P. Milburn, A. Ethala, , I. A. Cockburn

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

bioRxiv · May 28, 2020 · PreprintImmunology

Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses

H. A. McNamara, A. H. Idris, H. J. Sutton, B. J. Flynn, Y. Cai, K. Wiehe, K. E. Lyke, D. Chatterjee, N. KC, S. Chakravarty, K. L. Sim, S. L. Hoffman, M. Bonsignori, R. A. Seder, I. A. Cockburn

The paper shows antibody feedback limits memory B cell expansion but allows diversification of vaccine-induced antibody responses by suppressing dominant epitopes while enabling subdominant ones.

bioRxiv · Oct 18, 2019 · PreprintImmunology