miRISC inhibition causes mitotic defects and synergizes with genotoxic agents in cancers
Minsi Zhang, Ziqi Jiao, Ylenia Cendon Florez, Ivana Lessel, Xiaoyi Li, Melissa A. Yao, Moritz Weigl, Mateusz M. Ozimek, Turgut Dogruluk, Kevin Chen, Keith Conrad Fernandez, Vinagolu K. Rajasekhar, Olesja Popow, João A. Paulo, Davide Pradella, , Gaspare La Rocca
The paper shows that inhibiting the HMWR complex causes mitotic defects and enhances cancer cell vulnerability when combined with genotoxic agents.
bioRxiv · Dec 15, 2025 · PreprintCancer Biology