Incorporation of genome-bound cellular proteins into HIV-1 particles regulates viral infection
Manuel García-Moreno, Azman Embarc-Buh, Robin Truman, Marko Noerenberg, Louisa Iselin, Honglin Chen, Caroline E. Lenz, Jeffrey Y. Lee, Kate Dicker, Snehith Dyavari Shetty, Natasha Palmalux, Quan Gu, Thibault J. M. Sohier, Aino I. Järvelin, Wael Kamel, , Alfredo Castelló
This study identifies 104 cellular RNA-binding proteins within HIV-1 particles, revealing their role in viral gene expression and infectivity through interactions with HIV-1 genomic RNA.
Cell Reports · Apr 1, 2026Peer-reviewedMolecular Biology