Author

Isam Adam

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:scRNA-seq· 3 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Aaron J. LongworthiD· 4 shared Devon A. LawsoniD· 4 shared Kai KessenbrockiD· 4 shared Sharmila MallyaiD· 4 shared Angela Lincy Prem Antony SamyiD· 3 shared Dennis MaiD· 3 shared Hannah SavageiD· 3 shared Jacob Insua‐RodrígueziD· 3 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Aaron J. LongworthORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Restoration of deficient IL-15 signaling enhances innate lymphoid cell immunity in brain metastasis

Timothy P McMullen, Pascal Naef, Erika Zagni, Lei Tian, Eva Zhao, Noah Wechter, Aaron J. Longworth, Isam Adam, Jacob Insua‐Rodríguez, Hannah Savage, Isaac Hur, Sophia A. Garcia, Dennis Ma, Michael H Liew, Sharmila Mallya, , Devon A. Lawson

This study shows that restoring IL-15 signaling enhances group 1 ILCs' anti-tumor activity in brain metastasis, reducing tumor burden through improved cytotoxicity and tissue residency.

bioRxiv · Oct 10, 2026 · PreprintImmunology

Cell-of-origin shapes tumor subtype in BRCA1-associated triple-negative breast cancer

Tatyana Lev, Angela Lincy Prem Antony Samy, Sharmila Mallya, Isam Adam, Dana Pueschl, Dennis Ma, Timothy P McMullen, Mandeep S. Lev, Jessica G Gonzalez, Aaron J. Longworth, Arjun Nair, Xin Lu, Andrew K. Godwin, Paul Andrew James, Phuong L. Mai, , Devon A. Lawson

This study identifies two cell-of-origin-driven subtypes of BRCA1-associated TNBC, showing that tumor subtype depends on the cell type initiating the cancer.

bioRxiv · Sep 30, 2026 · PreprintCancer Biology

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer

Jacob Insua‐Rodríguez, Pascal Naef, Hannah Savage, Isam Adam, Sung Kook Chun, Axel A. Almet, Gautham Prabhakar, Sharon Kwon, Cassandra G Sweet, Sevilla Farah Hennessey, Angela Lincy Prem Antony Samy, Hamad S. Alshetaiwi, Maren Pein, Sharmila Mallya, Delia F. Tifrea, , Devon A. Lawson

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

bioRxiv · Feb 3, 2026 · PreprintCancer Biology

PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling

Paige V. Halas, Hannah Savage, Stephanie J. Hachey, Tatyana Lev, Angela Lincy Prem Antony Samy, Connie C.C. Chan, Stephanie Jimenez, Radhika M Domadia, Iana Lin, Sharmila Mallya, Jacob Insua‐Rodríguez, Jessica Gonzalez, Isam Adam, Hamad S. Alshetaiwi, Grace A. Hernandez, , Devon A. Lawson

This study identifies PHLDA2 as a driver of breast cancer metastasis by reactivating a placental vascular remodeling program through hypomethylation and SPARC-mediated effects.

bioRxiv · Aug 19, 2025 · PreprintCancer Biology