Sharmila Mallya

Restoration of deficient IL-15 signaling enhances innate lymphoid cell immunity in brain metastasis

This study shows that restoring IL-15 signaling enhances group 1 ILCs' anti-tumor activity in brain metastasis, reducing tumor burden through improved cytotoxicity and tissue residency.

Cell-of-origin shapes tumor subtype in BRCA1-associated triple-negative breast cancer

This study identifies two cell-of-origin-driven subtypes of BRCA1-associated TNBC, showing that tumor subtype depends on the cell type initiating the cancer.

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling

This study identifies PHLDA2 as a driver of breast cancer metastasis by reactivating a placental vascular remodeling program through hypomethylation and SPARC-mediated effects.

A spatially resolved single cell genomic atlas of the adult human breast

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.