Cryo-EM of ATP-driven dynamics and itraconazole binding of the fungal drug efflux ABC pump Candida glabrata Cdr1
Jorgaq Pata, Benjamin Wiseman, Eleftherios Zarkadas, Rim Baccouch, Nour Samrouth, Celia Desbois, Loïck Moissonnier, Alexis Moréno, Atanu Banerjee, Stephanie Aguero, Emmanuel Bettler, Marie Dujardin, Sandrine Magnard, Raphaël Terreux, Guy Schoehn, , Pierre Falson
The paper presents cryo-EM structures of the fungal ABC pump Cdr1, revealing its ATP-driven dynamics and drug-binding mechanism.
bioRxiv · Sep 22, 2025 · PreprintBiochemistry