Author

Ahcène Boumendjel

InsermORCID 0000-0002-1830-6409Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Arthur ReveillardiD· 2 shared Eleftherios ZarkadasiD· 2 shared Erwin LampingiD· 2 shared Fabien PierreliD· 2 shared Guy SchoehniD· 2 shared Jorgaq PataiD· 2 shared Nour Samrouth· 2 shared Pierre FalsoniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

Arthur ReveillardORCID

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Author profile →

4 papers

Recent·Most cited

Isoprenoid quinone profiling using a novel semi-quantitative HPLC-MS/MS method: application to wastewater sludges

Morgane Roger‐Margueritat, Arthur Reveillard, Caroline Plazy, Andrei Octavian Filimon, Ahcène Boumendjel, Volker F. Wendisch, Valérie Cunin, Sophie S. Abby, Audrey Le Gouëllec, Fabien Pierrel

This paper introduces a semi-quantitative HPLC-MS/MS method for detecting isoprenoid quinones in wastewater sludges, identifying 57 quinones across treatment stages.

bioRxiv · Sep 27, 2026 · PreprintBiochemistry

The immunosuppressant tacrolimus (FK506) inhibits C. glabrata Cdr1 efflux pump function by stabilizing the inward-facing conformation.

Rim Baccouch, Theo Benefice, Eleftherios Zarkadas, Nour Samrouth, Jorgaq Pata, Sandrine Magnard, Florent Di Meo, Raphaël Terreux, Stephanie Aguero, Ahcène Boumendjel, Guy Schoehn, Erwin Lamping, Pierre Falson, Vincent Chaptal

This paper reveals that tacrolimus inhibits C. glabrata Cdr1 by stabilizing its inward-facing conformation, blocking ATP hydrolysis and azole transport.

bioRxiv · Jul 8, 2026 · PreprintBiochemistry

Cryo-EM of ATP-driven dynamics and itraconazole binding of the fungal drug efflux ABC pump Candida glabrata Cdr1

Jorgaq Pata, Benjamin Wiseman, Eleftherios Zarkadas, Rim Baccouch, Nour Samrouth, Celia Desbois, Loïck Moissonnier, Alexis Moréno, Atanu Banerjee, Stephanie Aguero, Emmanuel Bettler, Marie Dujardin, Sandrine Magnard, Raphaël Terreux, Guy Schoehn, , Pierre Falson

The paper presents cryo-EM structures of the fungal ABC pump Cdr1, revealing its ATP-driven dynamics and drug-binding mechanism.

bioRxiv · Sep 22, 2025 · PreprintBiochemistry

A novel quinone biosynthetic pathway illuminates the evolution of aerobic metabolism

Felix J. Elling, Fabien Pierrel, Sophie-Carole Chobert, Sophie S. Abby, Thomas W. Evans, Arthur Reveillard, Ludovic Pélosi, Juliette Schnoebelen, Jordon D. Hemingway, Ahcène Boumendjel, Kevin W. Becker, Pieter Blom, Julia Cordes, Vinitra Nathan, Frauke Baymann, , Ann Pearson

The paper identifies a novel ancestral high redox potential quinone, methyl-plastoquinone, and shows its evolutionary origin predates the Great Oxygenation Event.

Proceedings of the National Academy of Sciences · Feb 20, 2025Peer-reviewedMicrobiology