Author

Pierre Falson

Lyon 1 UniversitéORCID 0000-0002-9760-4577Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Eleftherios ZarkadasiD· 3 shared Guy SchoehniD· 3 shared Raphaël TerreuxiD· 3 shared Sandrine MagnardiD· 3 shared Vincent ChaptaliD· 3 shared Ahcène BoumendjeliD· 2 shared Emmanuel BettleriD· 2 shared Erwin LampingiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Eleftherios ZarkadasORCID

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3 papers

Recent·Most cited

The immunosuppressant tacrolimus (FK506) inhibits C. glabrata Cdr1 efflux pump function by stabilizing the inward-facing conformation.

Rim Baccouch, Theo Benefice, Eleftherios Zarkadas, Nour Samrouth, Jorgaq Pata, Sandrine Magnard, Florent Di Meo, Raphaël Terreux, Stephanie Aguero, Ahcène Boumendjel, Guy Schoehn, Erwin Lamping, Pierre Falson, Vincent Chaptal

This paper reveals that tacrolimus inhibits C. glabrata Cdr1 by stabilizing its inward-facing conformation, blocking ATP hydrolysis and azole transport.

bioRxiv · Jul 8, 2026 · PreprintBiochemistry

Cryo-EM of ATP-driven dynamics and itraconazole binding of the fungal drug efflux ABC pump Candida glabrata Cdr1

Jorgaq Pata, Benjamin Wiseman, Eleftherios Zarkadas, Rim Baccouch, Nour Samrouth, Celia Desbois, Loïck Moissonnier, Alexis Moréno, Atanu Banerjee, Stephanie Aguero, Emmanuel Bettler, Marie Dujardin, Sandrine Magnard, Raphaël Terreux, Guy Schoehn, , Pierre Falson

The paper presents cryo-EM structures of the fungal ABC pump Cdr1, revealing its ATP-driven dynamics and drug-binding mechanism.

bioRxiv · Sep 22, 2025 · PreprintBiochemistry

R6G narrows BmrA conformational spectrum for a more efficient use of ATP

Alexia Gobet, Loïck Moissonnier, Eleftherios Zarkadas, Sandrine Magnard, Emmanuel Bettler, Juliette Martin, Raphaël Terreux, Guy Schoehn, Cédric Orelle, Jean‐Michel Jault, Pierre Falson, Vincent Chaptal

This study shows that Rhodamine6G binding to BmrA narrows its conformational spectrum, enhancing ATP-dependent transport efficiency.

Nature Communications · Feb 18, 2025Peer-reviewedBiochemistry