Author

Stephanie Aguero

Lyon 1 UniversitéORCID 0000-0002-9282-5506Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Raphaël TerreuxiD· 3 shared Ahcène BoumendjeliD· 2 shared Eleftherios ZarkadasiD· 2 shared Erwin LampingiD· 2 shared Guy SchoehniD· 2 shared Jorgaq PataiD· 2 shared Nour Samrouth· 2 shared Pierre FalsoniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Raphaël TerreuxORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

The immunosuppressant tacrolimus (FK506) inhibits C. glabrata Cdr1 efflux pump function by stabilizing the inward-facing conformation.

Rim Baccouch, Theo Benefice, Eleftherios Zarkadas, Nour Samrouth, Jorgaq Pata, Sandrine Magnard, Florent Di Meo, Raphaël Terreux, Stephanie Aguero, Ahcène Boumendjel, Guy Schoehn, Erwin Lamping, Pierre Falson, Vincent Chaptal

This paper reveals that tacrolimus inhibits C. glabrata Cdr1 by stabilizing its inward-facing conformation, blocking ATP hydrolysis and azole transport.

bioRxiv · Jul 8, 2026 · PreprintBiochemistry

Cryo-EM of ATP-driven dynamics and itraconazole binding of the fungal drug efflux ABC pump Candida glabrata Cdr1

Jorgaq Pata, Benjamin Wiseman, Eleftherios Zarkadas, Rim Baccouch, Nour Samrouth, Celia Desbois, Loïck Moissonnier, Alexis Moréno, Atanu Banerjee, Stephanie Aguero, Emmanuel Bettler, Marie Dujardin, Sandrine Magnard, Raphaël Terreux, Guy Schoehn, , Pierre Falson

The paper presents cryo-EM structures of the fungal ABC pump Cdr1, revealing its ATP-driven dynamics and drug-binding mechanism.

bioRxiv · Sep 22, 2025 · PreprintBiochemistry

Molecular docking, validation, dynamic simulation and pharmacokinetic prediction of natural compounds against Mycobacterium tuberculosis Beta-lactamase BlaC

Sandra Sreekumar, J.L Bhagya Jyothi, Liji Selvanose, Subhash Chandra Pani, Niya Elizaba Rajee, Stephanie Aguero, Raphaël Terreux, Immanuel Dhanasingh

This study identifies natural inhibitors against Mycobacterium tuberculosis BlaC using molecular docking and simulations, finding Tryptoquivaline K as a stable and promising inhibitor.

bioRxiv · Jan 7, 2025 · PreprintBioinformatics