Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection
Bo Jiang, Pengwei Ren, Changshun He, Mo Wang, Sae‐Il Murtada, María Jesús Ruiz-Rodríguez, Yu Chen, Abhay B. Ramachandra, Guangxin Li, Lingfeng Qin, Roland Assi, Martin Alexander Schwartz, Jay D. Humphrey, George Tellides
This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.
JCI Insight · Feb 11, 2025Peer-reviewedPathology