Author

Sae‐Il Murtada

Yale UniversityORCID 0000-0002-6578-4585Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Jay D. HumphreyiD· 2 shared Abhay B. RamachandraiD· 1 shared Anna O’DonnelliD· 1 shared Bo JiangiD· 1 shared Bruce CatersoniD· 1 shared Caroline M. Kraft· 1 shared Changshun He· 1 shared Christian Norvik· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPathology

Jay D. HumphreyORCID

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2 papers

Recent·Most cited

Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection

Bo Jiang, Pengwei Ren, Changshun He, Mo Wang, Sae‐Il Murtada, María Jesús Ruiz-Rodríguez, Yu Chen, Abhay B. Ramachandra, Guangxin Li, Lingfeng Qin, Roland Assi, Martin Alexander Schwartz, Jay D. Humphrey, George Tellides

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

JCI Insight · Feb 11, 2025Peer-reviewedPathology

Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

Sumeda Nandadasa, Jason M. Szafron, Vai Pathak, Sae‐Il Murtada, Caroline M. Kraft, Anna O’Donnell, Christian Norvik, Clare Hughes, Bruce Caterson, Miriam S. Domowicz, Nancy B. Schwartz, Karin Tran‐Lundmark, Martina L. Veigl, David Sedwick, Elliot H. Philipson, , Suneel Apte

The paper identifies differential proteoglycan dynamics in umbilical artery and vein as the mechanism ensuring rapid arterial closure and venous patency at birth.

eLife · Sep 10, 2020Peer-reviewedDevelopmental Biology