Roland Assi

Hydraulic fracturing-induced delamination and extravasation extends medial damage beyond the false lumen in aortic dissection

The paper investigates how hydraulic fracturing in aortic dissection causes medial damage beyond the false lumen, leading to structural weakening of the aortic wall.

Increased medial collagen enhances aortic resilience against mural delamination from hydraulic fracturing

This study investigates how increased medial collagen affects aortic resilience against mural delamination by analyzing pressure responses in human aortic specimens under different conditions.

Mechanisms Driving Thoracic Aortic Aneurysm Stability

This paper develops a computational biomechanical model to simulate thoracic aortic aneurysm progression and predict outcomes like stabilization or rupture.

Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues

The paper introduces Cryo-mtscATAC-seq to genotype mitochondrial DNA and trace clones in frozen human tissues, revealing clonal patterns in various diseases.

Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption

The paper analyzes single-cell transcriptomes of aortic smooth muscle cells in mice to show distinct origins and similar transcriptional changes after TGFβ signaling disruption.