Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules
Samuel Liu, Peng Xiao, Matthias Elgeti, Eve J. Fine, E Lucero, Mikkel Vestergaard, Junyan Wang, Arun Jyothidasan, Angus Li, Changxiu Qu, Eva Olsen, Georgios Mazis, Josephine K. Madsen, Carl‐Mikael Suomivuori, Ji Hee Kim, , Robert J. Lefkowitz
The paper identifies and characterizes small molecule allosteric modulators of the AT1R, revealing their conformational mechanisms and effects on G protein and β-arrestin pathways.
bioRxiv · Jul 16, 2026 · PreprintBiochemistry