Author

Dean P. Staus

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Matthias ElgetiiD· 2 shared Alem W. KahsaiiD· 1 shared Ali MasoudiiD· 1 shared Angus Li· 1 shared Arun Jyothidasan· 1 shared Carl‐Mikael SuomivuoriiD· 1 shared Changxiu Qu· 1 shared E Lucero· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Matthias ElgetiORCID

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Author profile →

2 papers

Recent·Most cited

Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules

Samuel Liu, Peng Xiao, Matthias Elgeti, Eve J. Fine, E Lucero, Mikkel Vestergaard, Junyan Wang, Arun Jyothidasan, Angus Li, Changxiu Qu, Eva Olsen, Georgios Mazis, Josephine K. Madsen, Carl‐Mikael Suomivuori, Ji Hee Kim, , Robert J. Lefkowitz

The paper identifies and characterizes small molecule allosteric modulators of the AT1R, revealing their conformational mechanisms and effects on G protein and β-arrestin pathways.

bioRxiv · Jul 16, 2026 · PreprintBiochemistry

Angiotensin receptor conformations stabilized by biased ligands differentially modulate β-arrestin interactions

Matthias Elgeti, Julia Belyaeva, Mahdi Bagherpoor Helabad, Dean P. Staus, Laura M. Wingler

The paper shows that biased ligands of the AT1R receptor stabilize different conformations that differentially modulate β-arrestin interactions, affecting signaling and desensitization.

Journal of Biological Chemistry · Dec 29, 2025Peer-reviewedBiochemistry