Author

Georgios Mazis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alem W. KahsaiiD· 1 shared Ali MasoudiiD· 1 shared Angus Li· 1 shared Anh T. Tran· 1 shared Arghya Sadhukhan· 1 shared Arun Jyothidasan· 1 shared Brian A. LanmaniD· 1 shared Carl‐Mikael SuomivuoriiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Alem W. KahsaiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules

Samuel Liu, Peng Xiao, Matthias Elgeti, Eve J. Fine, E Lucero, Mikkel Vestergaard, Junyan Wang, Arun Jyothidasan, Angus Li, Changxiu Qu, Eva Olsen, Georgios Mazis, Josephine K. Madsen, Carl‐Mikael Suomivuori, Ji Hee Kim, , Robert J. Lefkowitz

The paper identifies and characterizes small molecule allosteric modulators of the AT1R, revealing their conformational mechanisms and effects on G protein and β-arrestin pathways.

bioRxiv · Jul 16, 2026 · PreprintBiochemistry

LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation

Dhanusha A. Nalawansha, Georgios Mazis, Gitte Husemoen, Kate S. Ashton, Weixian Deng, Ryan P. Wurz, Anh T. Tran, Brian A. Lanman, Jiansong Xie, Robert G. Guenette, Shiqian Li, Christopher E. Smith, Suresh Archunan, Manoj K. Agnihotram, Arghya Sadhukhan, , Patrick Ryan Potts

This paper introduces LYMTACs, small molecules that use lysosomal membrane proteins to target and degrade membrane proteins, showing effectiveness against KRASG12D.

Nature Communications · Aug 21, 2025Peer-reviewedCancer Biology